Results 121 to 130 of about 302,461 (314)

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Representation of transport: A Rural Destination Analysis

, 2009
Moscovici’s social representations perspective is applied to a study of transport in a rural destination. The principles are demonstrated using empirical data from a questionnaire survey, developed following in-depth qualitative research.
Robbins, Derek K., Fletcher, John, Dickinson, Janet E.   +2 more
core   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Examining destination personality: Its antecedents and outcomes

, 2018
This study of Sardinia, Italy, an island destination in the Mediterranean Sea, examines the role of involvement on destination personality formation process.
Christina Geng-Qing Chi, Del Chiappa, Giacomo, Chi, Christina Geng-Qing, Giacomo Del Chiappa, Pan, Li, Li Pan   +5 more
core   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Destination Innovation Matrix: A framework for new tourism experience and market development

, 2018
Destination managers must consider whether to continue to consolidate their experiences and markets or innovate by developing new experiences and targeting new markets when planning their tourism destination development. Although these approaches are not
Gardiner, Sarah, Gardiner, S, Scott, N, Scott, Noel   +3 more
core   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

Promotional impact of image formation of an aboriginal tourist destination.

The purpose of this research is to present a thorough analysis of image formation among first-time visitors to an Aboriginal (Mi’kmaw) cultural site. The thesis is an initial attempt to examine theories in consumer behaviour and reformulate a model in ...
Pyke, Joanne Lynn
core  

Impact of Destination Brand Experience to Increase Destination Brand Loyalty

Jurnal Aplikasi Manajemen
Research related to brand loyalty is important, especially in the period following the Covid-19 pandemic. At that time, many tourism destinations and businesses were destroyed and tended to go bankrupt, so a strategy was needed to revive brand loyalty in
Miska Irani Tarigan, Esli Silalahi, Anitha Paulina Tinambunan, Errie Margery, Lusiah Lusiah   +4 more
doaj   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source