Results 31 to 40 of about 952 (119)
Frontiers in Cardiovascular Medicine, 2015 Background: Hypoxia pulmonary arterial hypertension (HPAH) is a disease of the small vessels characterized by sustained vasoconstriction, thickening of arterial walls, vascular remodelling, and progressive increase in pulmonary vascular resistance, thus ...
Bin eYi +8 more
doaj +1 more source
Journal of Extracellular Vesicles, Volume 9, Issue 1, September 2020., 2020 ABSTRACT Astrocytes in the central nervous system (CNS) provide supportive neural functions and mediate inflammatory responses from microglia. Increasing evidence supports their critical roles in regulating brain homoeostasis in response to pro‐inflammatory factors such as cytokines and pathogen/damage‐associated molecular pattern molecules in ...
Yang You +5 more
wiley +1 more source
Cell Structure and Function, 1996 1. Cofilin is an essential actin-regulating protein widely distributed in all eucaryotes. The structure and function of cofilin are conserved during evolution. 2. Cofilin depolymerizes F-actin in vitro at alkaline pH and severs F-actin in vitro at pH lower than 7.3. Overexpression of cofilin in viable cells induced bundles of actin filaments suggesting
Yahara, Ichiro +7 more
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Bioscience, Biotechnology, and Biochemistry, 1998 The amino acid sequences of destrin and cofilin are very similar (84% homology) throughout the entire range of proteins, but they have different functions. In this study, we constructed a new cofilin expression plasmid, which had high expression frequency, and the structures of destrin and cofilin were analyzed by limited proteolysis and circular ...
ARIMA, Kazunari +4 more
openaire +2 more sources
Physiological Reports, Volume 13, Issue 24, December 2025.Aging contributes to impairments in pulmonary microvascular endothelial cell‐cell junctions and barrier function, leading to an increased predisposition to injury. Created in BioRender. Gill, S. (2025) https://BioRender.com/l14r5v8 Abstract Pulmonary microvascular endothelial cell (PMVEC) intercellular junctions are critical for maintaining barrier ...
Aminmohamed Manji +10 more
wiley +1 more source
Aberrant actin cytoskeleton leads to accelerated proliferation of corneal epithelial cells in mice deficient for destrin (actin depolymerizing factor) [PDF]
Human Molecular Genetics, 2003 Corneal disease is the most common cause of bilateral blindness in the world. Visual loss in this condition is often due to changes in morphology and function of the corneal epithelial surface. Corneal disease-1 (corn1) and corn1(2J) are spontaneous mouse mutants that develop irregular thickening of the corneal epithelium, similar to that observed in ...
Sakae, Ikeda +8 more
openaire +2 more sources
Pharmacology Research &Perspectives, Volume 13, Issue 2, April 2025.ABSTRACT Heart failure (HF) is a leading cause of morbidity and mortality, often driven by prolonged exposure to pathological stimuli such as pressure and volume overload. These factors contribute to excessive oxidative stress, adverse cardiac remodeling, and dysregulation of the nitric oxide‐soluble guanylate cyclase‐cyclic guanosine monophosphate (NO‐
Adriana Martišková +8 more
wiley +1 more source
The effect of destrin mutations pathways on the gene expression profile
African Journal of Microbiology Research, 2012 Corneal disease is responsible for the main cause of bilateral blindness in the world, second only to cataract. As an essential actin binding protein, destrin mutation often result in cytoskeleton dynamics abnormalities in corneal epithelial surface, and thus, cause corneal epithelial cell hyperproliferation, inflammation, and angiogenesis, namely ...
openaire +1 more source
Secretomes of Gingival Fibroblasts From Periodontally Diseased Tissues: A Proteomic Analysis
Clinical and Experimental Dental Research, Volume 11, Issue 1, February 2025.ABSTRACT Objective Cell secretomes represent a promising strategy for periodontal and bone regeneration. The objective of this study was to characterize the secretome of human gingival fibroblasts (GF) from periodontally diseased tissues (GF‐perio) using proteomics. Materials and Methods Conditioned media of GF‐perio from periodontitis patients (n = 6,
Anne Kari Smedås +7 more
wiley +1 more source
Experimental and Therapeutic Medicine, 2013 The aim of this study was to investigate the effects of actin depolymerizing factor (ADF)/destrin and position changes of kinetosomes in the development of hair cells following Atoh1-induced ectopic regeneration in the basilar membrane of mice. We observed through immunofluorescence at various time-points the expression of ADF/destrin and the specific ...
JIN, KAI +5 more
openaire +3 more sources