Results 11 to 20 of about 952 (119)

How Growth Cones Sense Extracellular Cues and Drive Neuronal Migration: Shared Mechanisms Between Growth Cones of Migrating Neurons and Axons. [PDF]

Bioessays
Migrating neurons and growing axons utilize structurally and functionally similar growth cones to detect guidance cues. Shared receptors and signaling pathways mediate cytoskeletal reorganization to direct movement. This conserved mechanism underlies both neuronal migration and axon extension, providing insights into neuronal development and potential ...
Kanzawa T, Nakajima C, Sawada M, Sawamoto K.   +3 more
europepmc   +2 more sources

Highly divergent apicomplexan cytoskeletons provide additional models for actin biology. [PDF]

FEBS J
Actin is a highly conserved, abundant and central molecule in eukaryotes. Apicomplexans contain some of the most sequence‐divergent actin cytoskeletons known. This divergence results in overlapping yet different biochemical properties. Here, we highlight the remarkable divergence of the actin cytoskeleton by comparing apicomplexan to classical systems,
Kobayashi Y, Douglas RG.
europepmc   +2 more sources

Actin Depolymerizing Factor Destrin Regulates Cilia Development and Function during Vertebrate Embryogenesis. [PDF]

Dev Reprod
The actin cytoskeleton plays fundamental roles in ciliogenesis and the actin depolymerizing factor destrin regulates actin dynamics by treadmilling actin filaments and increasing globular actin pools. However, the specific developmental roles of destrin in ciliogenesis have not been fully elucidated.
Kim Y, Lee HK, Park KY, Ismail T, Lee H, Lee HS.   +5 more
europepmc   +3 more sources

Actin-Binding Proteins as Potential Biomarkers for Chronic Inflammation-Induced Cancer Diagnosis and Therapy. [PDF]

Anal Cell Pathol (Amst), 2021
Actin‐binding proteins (ABPs), by interacting with actin, regulate the polymerization, depolymerization, bundling, and cross‐linking of actin filaments, directly or indirectly, thereby mediating the maintenance of cell morphology, cell movement, and many other biological functions.
Zhang YG, Niu JT, Wu HW, Si XL, Zhang SJ, Li DH, Bian TT, Li YF, Yan XK.   +8 more
europepmc   +2 more sources

3D Printing of Extracellular Matrix‐Based Multicomponent, All‐Natural, Highly Elastic, and Functional Materials toward Vascular Tissue Engineering

Advanced Healthcare Materials, Volume 12, Issue 20, August 8, 2023., 2023
3D‐printed, multicomponent, hyper‐elastic graft for vascular tissue engineering is developed. The bioink consists of decellularized aorta, tyramine‐modified hyaluronic acid, and alginate. The emerged graft induces angiogenesis, does not lead immunological reactions, and is perfusable.
Melis Isik, Ece Karakaya, Tugba Sezgin Arslan, Deniz Atila, Yasar Kemal Erdogan, Yavuz Emre Arslan, Hakan Eskizengin, Cemil Can Eylem, Emirhan Nemutlu, Batur Ercan, Matteo D'Este, Babatunde O. Okesola, Burak Derkus   +12 more
wiley   +1 more source

EVL Promotes Osteo‐/Odontogenic Differentiation of Dental Pulp Stem Cells via Activating JNK Signaling Pathway

Stem Cells International, Volume 2023, Issue 1, 2023., 2023
Objective. Human dental pulp stem cells (hDPSCs) were recognized as a suitable and promising source of stem cells in dental pulp regeneration. However, the mechanism by which hDPSCs differentiation into osteo‐/odontogenic lineage remains unclear. Ena/VASP‐like protein (EVL) has been found to be involved in diverse biological processes.
Kangrui Zeng, Qiongyi Kang, Yutong Li, Weiping Li, Qing Cheng, Wenwei Xia, Federico Mussano   +6 more
wiley   +1 more source

Bio‐Mimicking Brain Vasculature to Investigate the Role of Heterogeneous Shear Stress in Regulating Barrier Integrity

Advanced Biology, Volume 6, Issue 12, December 2022., 2022
Fabrication of a lithography‐less Cayley‐tree pattern to generate a blood‐brain barrier‐on‐a‐chip. The shape of the microchannels in the Cayley‐tree pattern is semi‐elliptical with smooth variation in the height of the microchannels from the parent branch to daughter branches.
Ami Mehta, Anal Desai, David Rudd, Ghizal Siddiqui, Cameron J. Nowell, Ziqiu Tong, Darren J. Creek, Prakriti Tayalia, Prasanna S. Gandhi, Nicolas H. Voelcker   +9 more
wiley   +1 more source

Extracellular vesicles released by steatotic hepatocytes alter adipocyte metabolism

Journal of Extracellular Biology, Volume 1, Issue 2, February 2022., 2022
Abstract The composition of extracellular vesicles (EVs) is altered in many pathological conditions, and their molecular content provides essential information on features of parent cells and mechanisms of crosstalk between cells and organs. Metabolic Syndrome (MetS) is a cluster of clinical manifestations including obesity, insulin resistance ...
J.E. Mleczko, F. Royo, I. Samuelson, M. Clos‐Garcia, C. Williams, D. Cabrera, M. Azparren‐Angulo, E. Gonzalez, C. Garcia‐Vallicrosa, S. Carobbio, S. Rodriguez‐Cuenca, M. Azkargorta, S. van Liempd, F. Elortza, A. Vidal‐Puig, S. Mora, J.M. Falcon‐Perez   +16 more
wiley   +1 more source

Characterization of Cellular Heterogeneity and an Immune Subpopulation of Human Megakaryocytes

Advanced Science, Volume 8, Issue 15, August 4, 2021., 2021
By performing single‐cell transcriptomic analysis of human megakaryocytes from native bone marrow, the megakaryocyte heterogeneity is revealed, an immune subpopulation marked by CD148 and CD48 is discovered, and the potential function of immune megakaryocytes as immune‐surveillance cells is elucidated.
Cuicui Liu, Dan Wu, Meijuan Xia, Minmin Li, Zhiqiang Sun, Biao Shen, Yiying Liu, Erlie Jiang, Hongtao Wang, Pei Su, Lihong Shi, Zhijian Xiao, Xiaofan Zhu, Wen Zhou, Qianfei Wang, Xin Gao, Tao Cheng, Jiaxi Zhou   +17 more
wiley   +1 more source

Identification and characterization of hADSC‐derived exosome proteins from different isolation methods

Journal of Cellular and Molecular Medicine, Volume 25, Issue 15, Page 7436-7450, August 2021., 2021
Abstract Exosomes are secreted into the extracellular space by most cell types and contain various molecular constituents, which play roles in many biological processes. Adipose‐derived mesenchymal stem cells (ADSCs) can differentiate into a variety of cell types and secrete a series of paracrine factors through exosomes.
Lien‐Hung Huang, Cheng‐Shyuan Rau, Shao‐Chun Wu, Yi‐Chan Wu, Chia‐Jung Wu, Chia‐Wen Tsai, Chia‐Wei Lin, Tsu‐Hsiang Lu, Ching‐Hua Hsieh   +8 more
wiley   +1 more source