Actin depolymerizing factor destrin governs cell migration in neural development during Xenopus embryogenesis [PDF]
Molecules and Cells: The actin-based cytoskeleton is considered a fundamental driving force for cell differentiation and development. Destrin (Dstn), a member of the actin-depolymerizing factor family, regulates actin dynamics by treadmilling actin filaments and increasing
Youni Kim +10 more
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Actin Depolymerizing Factors Cofilin1 and Destrin Are Required for Ureteric Bud Branching Morphogenesis [PDF]
PLoS Genetics, 2010 The actin depolymerizing factors (ADFs) play important roles in several cellular processes that require cytoskeletal rearrangements, such as cell migration, but little is known about the in vivo functions of ADFs in developmental events like branching ...
Walter Witke +2 more
exaly +6 more sources
Interleukin-38 interacts with destrin/actin-depolymerizing factor in human keratinocytes. [PDF]
PLoS ONE, 2019 Interleukin (IL)-38 is a member of the IL-1 family of cytokines, which was proposed to exert anti-inflammatory effects. IL-38 is constitutively expressed in the skin, where keratinocytes are the main producing cells.
Dominique Talabot-Ayer +8 more
doaj +7 more sources
American Journal of Physiology - Heart and Circulatory Physiology, 2021 First, DSTN is selectively expressed in SMC in RhoA/SRF-dependent manner. Second, a SMC-selective enhancer just upstream of DSTN TSS harbors functional SRF, SMAD, and Notch/RBPJ binding elements. Third, DSTN depletion increased SRF-dependent SMC marker gene expression while inhibiting SMC migration and proliferation.
Joan Taylor, Kuo-An Liao
exaly +4 more sources
Journal of Immunology Research, 2021 To mimic Alzheimer’s disease, transgenic mice overexpressing the amyloid precursor protein (APP) were used in this study. We hypothesize that the neuroprotective effects of ETAS®50, a standardized extract of Asparagus officinalis stem produced by Amino ...
Zhanglong Peng +10 more
doaj +2 more sources
Bioinformatics Analysis and Experimental Validation of Disulphidptosis in Oral Squamous Cell Carcinoma [PDF]
International Dental JournalIntroduction and Aims: Oral squamous cell carcinoma (OSCC) is a highly aggressive relatively common cancer that poses a serious threat to patient health, leading to significant economic burdens on healthcare systems.
Xuhui Zhang +5 more
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Tetramethylpyrazine ameliorates LPS-induced acute lung injury via the miR-369-3p/DSTN axis [PDF]
Scientific ReportsAcute lung injury (ALI) is a severe clinical respiratory condition characterized by high rates of mortality and morbidity, for which effective treatments are currently lacking.
Weiting Tao +7 more
doaj +2 more sources
Defects in actin dynamics lead to an autoinflammatory condition through the upregulation of CXCL5. [PDF]
PLoS ONE, 2008 Destrin (DSTN) is a member of the ADF/cofilin family of proteins and is an important regulator of actin dynamics. The primary function of destrin is to depolymerize filamentous actin into its monomeric form and promote filament severing.
Angela M Verdoni +3 more
doaj +1 more source
Comparative analyses of longissimus muscle miRNAomes reveal microRNAs associated with differential regulation of muscle fiber development between Tongcheng and Yorkshire pigs. [PDF]
PLoS ONE, 2018 Tongcheng (TC) and Yorkshire (YK) are two pig breeds with distinctive muscle morphology. Porcine microRNAome (miRNAome) of the longissimus muscle during five developmental stages (40, 55, 63, 70, and 90 days post coitum (dpc)) was explored by Solexa ...
Yu Xi +10 more
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Saintika Medika, 2017 Pengaruh Pemberian Minyak Deep Frying Terhadap Perubahan Histopatologi Jantung Tikus Putih (Rattus novergicus strain wistar). Latar belakang: Peningkatan harga minyak tiap tahunnya mengakibatkan banyak masyarakat menggunakan minyak goreng berulang kali ...
Lianda Destrin Nurfadilah +2 more
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