Results 91 to 100 of about 3,670,867 (254)

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Editorial: Working Dogs: Form and Function, Volume II

Frontiers in Veterinary Science, 2021
Nathaniel J. Hall, Cynthia M. Otto, Cynthia M. Otto, Wendy I. Baltzer   +3 more
doaj   +1 more source

Three new Phytophthora detection methods, including training dogs to sniff out the pathogen, prove reliable

California Agriculture, 2018
Multiple species of Phytophthora have been identified in production facilities of plants used in reforestation and restoration projects. There's a risk that infected plant stock will lead to Phytophthora species establishing and spreading in habitats ...
Tedmund J. Swiecki, Matt Quinn, Laura Sims, Elizabeth Bernhardt, Lauralea Oliver, Tina Popenuck, Matteo Garbelotto   +6 more
doaj   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Dog-directed parenting components.

, 2018
Dog owning parents (N = 518) reported on dog-directed parenting in 32 items adapted from the Parenting Styles and Dimensions Questionnaire (PSDQ). Answers on a five-point Likert scale were analysed by Principal Component Analysis and presented are the ...
Marc Naguib (240897), Ineke R. van Herwijnen (4885387), Bonne Beerda (4885384), Joanne A. M. van der Borg (787946)   +3 more
core   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Editorial: Canine Olfactory Detection

Frontiers in Veterinary Science, 2020
Claire Guest, Cynthia M. Otto, Cynthia M. Otto   +2 more
doaj   +1 more source

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

Novel application of a conservation detection dog to recover wildlife telemetry equipment

Animal Biotelemetry
Background Wildlife tracking technologies are increasingly used to study animal behaviour, inform conservation management, and answer fundamental questions in ecology.
Shoshana Rapley, Heather M. McGinness, Claudio Sillero-Zubiri, Micha V. Jackson, Maldwyn J. Evans, Iain J. Gordon, Robert Heinsohn, Adrian D. Manning   +7 more
doaj   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source