Results 81 to 90 of about 242,070 (288)

Maintenance energy requirements of odor detection, explosive detection and human detection working dogs

PeerJ, 2015
Despite their important role in security, little is known about the energy requirements of working dogs such as odor, explosive and human detection dogs. Previous researchers have evaluated the energy requirements of individual canine breeds as well as dogs in exercise roles such as sprint racing.
Rebecca A. Mullis, Angela L. Witzel, Joshua Price   +2 more
openaire   +3 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Comparing the costs and detectability of bobcat using scat‐detecting dog and remote camera surveys in central Wisconsin

Wildlife Society Bulletin, 2015
Determining cost‐effective field methods for detecting carnivores is critical for effective survey and monitoring studies. As the bobcat (Lynx rufus) undergoes range expansion in the northern and eastern United States, field methods may be useful for ...
John D. J. Clare, Eric M. Anderson, David M. MACfarland, Brian L. Sloss   +3 more
doaj   +1 more source

Phylogenetic relationships of Cryptosporidium parasites based on the 70- kilodalton heat shock protein (HSP70) gene [PDF]

, 2000
We have characterized the nucleotide sequences of the 70-kDa heat shock protein (HSP70) genes of Cryptosporidium baileyi, C. felis, C. meleagridis, C. muris, C. serpentis, C. wrairi, and C. parvum from various animals.
Sulaiman, I., Morgan, U.M., Thompson, R.C.A., Lal, A.A., Xiao, L.   +4 more
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Using detection dogs to conduct simultaneous surveys of northern spotted (Strix occidentalis caurina) and barred owls (Strix varia).

PLoS ONE, 2012
State and federal actions to conserve northern spotted owl (Strix occidentalis caurina) habitat are largely initiated by establishing habitat occupancy.
Samuel K Wasser, Lisa S Hayward, Jennifer Hartman, Rebecca K Booth, Kristin Broms, Jodi Berg, Elizabeth Seely, Lyle Lewis, Heath Smith   +8 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Detection Dogs Working in Hot Climates: The Influence on Thermoregulation and Fecal Consistency

Animals
Body temperature is an important physiological parameter that influences the performance of working dogs. The main cooling mechanism in dogs is panting to support evaporative cooling, which reduces the dog’s ability to detect scents.
Leopold Slotta-Bachmayr, Antony Oyugi, Noreen Mutoro, Mary Burak, Mary Wykstra   +4 more
doaj   +1 more source

The Application of Two-level Attention Models in Deep Convolutional Neural Network for Fine-grained Image Classification

, 2014
Fine-grained classification is challenging because categories can only be discriminated by subtle and local differences. Variances in the pose, scale or rotation usually make the problem more difficult. Most fine-grained classification systems follow the
Peng, Yuxin, Xiao, Tianjun, Xu, Yichong, Yang, Kuiyuan, Zhang, Jiaxing, Zhang, Zheng   +5 more
core   +1 more source