Results 111 to 120 of about 240,773 (297)

Effect of rejection on electrophysiologic function of canine intestinal grafts: Correlation with histopathology and na-k-ATPase activity [PDF]

, 1995
To investigate whether electrophysiologic changes can detect the early onset and progress of intestinal rejection, changes in in vitro electrophysiologic function, intestinal histopathology, and Na-K-ATPase activity were studied in dogs.
Billiar T R, Charney A N, Charney A N, Cohen W B, Dennison A R, Esmann M, Grant D, Kirkman R L, Lee M D, Lee T K, Madara J L, Meijssen M AC, Millard P R, Murase N, Murase N, Nakahara S, Nakamura K, Nordgren S, Quigley J P, Rosemurgy A S, Schamaun M, Schiller W R, Schmid T, Schroeder P, Stanford W P, Todo S, Todo S, Yoshimi F   +27 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

A Leishmania infantum FML-ELISA for the Detection of Symptomatic and Asymptomatic Canine Visceral Leishmaniasis in an Endemic Area of Iran [PDF]

Background: Visceral leishmaniasis (VL) is caused by Leishmania infantum in Mediterranean basin and is an endemic disease in some parts of Iran. Canines are the main reservoirs of VL in most of the endemic areas.
بهلولی, شهاب, جبیری پور, منصوره, حاتم, غلامرضا, زارعی, ذبیح اله, سرکاری, بهادر, محبعلی, مهدی, محمدی قلعه بین, بهنام   +6 more
core  

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

You Are Not My Handler! Impact of Changing Handlers on Dogs’ Behaviours and Detection Performance

Animals, 2018
Dog-handler relationships can directly impact team success. Changing a dog’s handler may therefore compromise detection performance. However, there are currently few studies which support this. This research explored the performance and behavioural
La Toya J. Jamieson, Greg S. Baxter, Peter J. Murray   +2 more
doaj   +1 more source

Therapeutic efficacy of microtube-embedded chondroitinase ABC in a canine clinical model of spinal cord injury [PDF]

, 2018
Many hundreds of thousands of people around the world are living with the long-term consequences of spinal cord injury and they need effective new therapies.
Albin, Barritt, Bartus, Biering-Sørensen, Bowes, Bradbury, Bradbury, Cafferty, Combrisson, Crespo, da Costa, Fawcett, Frank, Freedman, Gallucci, Garcia-Alias, Granger, Griffiths, Gutierrez-Quintana, Hamilton, Harris, Hilary Z Hu, Jefferson, Kwon, Kwon, Kwon, Lankhorst, Lee, Levine, Lin, Massey, Metz, Moore, Nashmi, Nick D Jeffery, Nicolas Granger, Nollet, Poncelet, Ravi V Bellamkonda, S Balakrishna Pai, Smith, Sylvestre, Tetzlaff, Toppercer, Watzlawick, Wicki, Yick   +46 more
core   +2 more sources

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Erratum: Enhancing the Selection and Performance of Working Dogs

Frontiers in Veterinary Science, 2022
Frontiers Production Office
doaj   +1 more source