Results 111 to 120 of about 2,243,348 (294)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Correlation of Calibration Parameters for HPGe Detector Efficiency Based on Monte Carlo Simulation

Yuanzineng kexue jishu
During the operation, maintenance, and eventual decommissioning of nuclear power plants, a significant amount of low and intermediate-level radioactive waste is generated.
LI Yan1, SHAN Chenyu2, GU Weiguo1, WANG Dezhong1
doaj   +1 more source

An algorithm for estimating the detection efficiency of a lightning location system

Geomatics, Natural Hazards & Risk, 2019
This article puts forward an algorithm for estimating the detection efficiency (DE) of a lightning location system (LLS). The algorithm can be applied to lightning flash/stroke density correction and LLS performance evaluation.
HaiBo Hu, Ying Wang, Xiya Zhang
doaj   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Analysis of Radiation Methods for Explosive Materials Detection

East European Journal of Physics
The paper examines the physical aspects of some landmine detection methods based on fast neutron backscattering. An analysis of the reaction products of the interaction of fast, slow, and thermal neutrons with H, C, N, O nuclei, which are part of ...
G. Onyshchenko, I. Yakymenko, O. Sidletskiy, P. Kuznietsov, O. Tarasenko, O. Shchus, I. Tolkunov, O. Kudin, O. Kuzin, A. Dobrozhan, S. Lytovchenko   +10 more
doaj   +1 more source

Security proof of quantum key distribution with detection efficiency mismatch [PDF]

, 2008
In theory, quantum key distribution (QKD) offers unconditional security based on the laws of physics. However, as demonstrated in recent quantum hacking theory and experimental papers, detection efficiency loophole can be fatal to the security of ...
Fung, Chi-Hang Fred, Lo, Hoi-Kwong, Ma, Xiongfeng, Qi, Bing, Tamaki, Kiyoshi   +4 more
core  

Effective and Efficient Model Clone Detection [PDF]

, 2015
Code clones are a major source of software defects. Thus, it is likely that model clones (i.e., duplicate fragments of models) have a significant negative impact on model quality, and thus, on any software created based on those models, irrespective of whether the software is generated fully automatically (“MDD-style”) or hand-crafted following the ...
openaire   +2 more sources

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source