Results 151 to 160 of about 907,313 (267)

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Impact of Device Architecture on Proton Detection Efficiency in 2D Perovskite Thick Film Detectors. [PDF]

Small
Napolitano G, Cepić S, Fratelli I, Chiari M, Fraboni B, Basiricò L.   +5 more
europepmc   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Effects of Microwave on Mortality and Detection Efficiency of Three Stored Grain Insect Adults in Stored Paddy, and on Grain Quality. [PDF]

Insects
Miao S, Zhou Y, Wang S, Yang Z, Guverinoma A, Zhao Y, Lu Y.   +6 more
europepmc   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Surpassing 99% detection efficiency by cascading two superconducting nanowires on one waveguide with self-calibration. [PDF]

Light Sci Appl
Li ZG, Mao J, Zhou YJ, Guo JW, Chen S, Hao H, Huang YH, Ru SY, Liu NT, Liu Z, Deng J, Yang F, Tu XC, Zhang LB, Jia XQ, Chen J, Kang L, Wang J, Zhao QY, Gong Q, Wu PH.   +20 more
europepmc   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Optimizing TB Bacteria Detection Efficiency: Utilizing RetinaNet-Based Preprocessing Techniques for Small Image Patch Classification. [PDF]

Int J Biomed Imaging
V S, Banerjee B, Laxmi V, Kamath P.
europepmc   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

A Statistical Framework of Watermarks for Large Language Models: Pivot, Detection Efficiency and Optimal Rules. [PDF]

Ann Stat
Li X, Ruan F, Wang H, Long Q, Su WJ.
europepmc   +1 more source