Results 141 to 150 of about 6,940,219 (310)

The Impact of Accumulated Mutations in SARS-CoV-2 Variants on the qPCR Detection Efficiency. [PDF]

Front Cell Infect Microbiol, 2022
Cao L, Xu T, Liu X, Ji Y, Huang S, Peng H, Li C, Guo D.   +7 more
europepmc   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Report of the Efficiency and Economy Committee on the educational institutions of Kansas

, 1916
Title from caption.The University -- The Agricultural College -- The Emporia Normal -- The Pittsburg Normal -- The Hays Normal -- The School for the Deaf -- The School for the Blind -- Western University -- The Topeka Institute -- The School of Mines ...
Kansas. Legislature. Efficiency and Economy Committee.
core   +1 more source

Time-domain based evaluation of detection efficiency in liquid scintillation counting. [PDF]

Sci Rep, 2021
Mitev K, Dutsov C, Cassette P, Sabot B.
europepmc   +1 more source

Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers

FEBS Letters, EarlyView.
Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui, Agnes Banreti, Armelle L. Ernst, Guillaume Leseigneur, Uwe J. Meierhenrich   +4 more
wiley   +1 more source

Improving the detection capability and efficiency of SARS-CoV-2 RNA specimens by the specimen turn-around process with multi-department cooperation

Frontiers in Public Health
ObjectiveImproving the detection capability and efficiency of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA specimens is very important for the prevention and control of the outbreak of Coronavirus disease 2019 (COVID-19).
Chenggui Liu, Wei Shen, Huiqiong Xie, Ying Li, Rong Cui, Rongcheng Wu, Li Xiao, Jing Li, Yanjun Guo, Yi Liao, Chonghui Zhao, Yunfei Xu, Qin Wang   +12 more
doaj   +1 more source

2.5D microscopy with polarization independent SLM for enhanced detection efficiency and aberration correction. [PDF]

Opt Express, 2021
Ren J, Han KY.
europepmc   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Quantification of Light Scattering Detection Efficiency and Background in Flow Cytometry. [PDF]

Cytometry A, 2021
de Rond L, Coumans FAW, Welsh JA, Nieuwland R, van Leeuwen TG, van der Pol E.   +5 more
europepmc   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source