Results 161 to 170 of about 7,324,417 (308)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

Business and industry e, energy, resources

open access: yes, 2005
Title from p. [1] of PDF (viewed Mar. 13, 2006).; "Created: 9/7/2005...; Modified 9/21/2005"--Document properties screen.; Designed to be printed on one sheet, front and back, and then folded into a pamphlet.; Harvested from the web on 3/14/06Lists low ...
Ohio. Office of Energy Efficiency.
core  

Efficient MIMO Detection Methods.

open access: yes, 2014
For the past decades, the demand in transferring large amounts of data rapidly and reliably has been increasing drastically. One of the more promising techniques that can provide the desired performance is multiple-input multiple-output (MIMO) technology where multiple antennas are placed at both the transmitting and receiving side of the communication
openaire   +2 more sources

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

open access: yesMolecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura   +19 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

open access: yesMolecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur   +11 more
wiley   +1 more source

Intelligent Green Efficiency for Intrusion Detection

open access: yes
Artificial Intelligence (AI) has emerged in popularity recently, recording great progress in various industries. However, the environmental impact of AI is a growing concern, in terms of the energy consumption and carbon footprint of Machine Learning (ML) and Deep Learning (DL) models, making essential investigate Green AI, an attempt to reduce the ...
Pedro Pereira   +4 more
openaire   +2 more sources

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

open access: yesMolecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic   +15 more
wiley   +1 more source

Peripheral zone PSA density: a predominant variable to improve prostate cancer detection efficiency in men with PSA higher than 4 ng ml-1. [PDF]

open access: yesAsian J Androl, 2021
Wang C   +11 more
europepmc   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

open access: yesMolecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang   +9 more
wiley   +1 more source

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