Results 151 to 160 of about 2,419,010 (304)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Metabolomics variable selection and classification in the presence of observations below the detection limit using an extension of ERp [PDF]

, 2017
Mari van Reenen, Johan A. Westerhuis, Carolus J. Reinecke, J. H. Venter   +3 more
openalex   +1 more source

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source

X-ray-Induced Pyroelectric Effect in a Perovskite Ferroelectric Drives Low Detection Limit Self-Powered Responses. [PDF]

ACS Cent Sci, 2023
Ma Y, Li W, Liu Y, Guo W, Xu H, Han S, Tang L, Fan Q, Luo J, Sun Z.   +9 more
europepmc   +1 more source

Design of Pitch Limit Detection Algorithm for Submarine

, 2016
Jong-Yong Park, Nakwan Kim, Yong-Ku Shin
openalex   +1 more source

Peer Review #1 of "Tree variability limits the detection of nutrient treatment effects on sap flux density in a northern hardwood forest (v0.3)"

, 2022
Alexandrea M. Rice, Mariann Johnston, Arianna Libenson, Ruth D. Yanai, J Aber, C Federer, V Amrhein, S Greenland, B Mcshane, J Battles, T Fahey, C Driscoll, J Blum, C Johnson, E Brzostek, D Dragoni, H Schmid, A Rahman, D Sims, C Wayson, D Johnson, R Phillips, M Clearwater, F Meinzer, J Andrade, G Goldstein, N Holbrook, A Coble, M Vadeboncoeur, Z Berry, K Jennings, C Mcintire, M Cramer, V Hoffmann, G Verboom, C Da Silva, J Goncalves, C Feldpausch, T, M Daley, N Phillips, C Pettijohn, J Hadley, A Escudero, J Del Arco, I Sanz, J Ayala, B Ewers, D Mackay, S Gower, D Ahl, S Burrows, S Samanta, F Fatemi, I Fernandez, J Szillery, S Norton, L Rustad, V Flo, J Martinez-Vilalta, K Steppe, B Schuldt, R Poyatos, J Foley, S Levis, M Costa, W Cramer, D Pollard, K Gonzales, R Yanai, S Goswami, M Fisk, M Vadeboncoeur, M Garrison-Johnston, R Yanai, T Fahey, A Granier, A Granier, M Green, A Bailey, S Bailey, J Battles, J Campbell, C Driscoll, T Fahey, L Lepine, G Likens, S Ollinger, P Schaberg, L Gu, S Pallardy, K Hosman, Y Sun, K Hayhoe, C Wake, B Anderson, X.-Z Liang, E Maurer, J Zhu, J Bradbury   +99 more
openalex   +2 more sources

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Hitting the Detection Limit in cAMP Signaling. [PDF]

Function (Oxf), 2022
Klein F, Machado MR, Pantano S.
europepmc   +1 more source

Effectiveness of hairpin probe in increasing the limit of detection for gold nanowire based-biosensor [PDF]

, 2014
Huu Tien Cao, Xuan Thanh Tung Pham, Van Linh Ha, Lê Văn Hiếu   +3 more
openalex   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source