Results 41 to 50 of about 541,940 (268)

An ecological perspective on the temporal variation in Pileated Woodpecker ( Dryocopus pileatus ) drumming behavior in Alberta, Canada

Avian Conservation and Ecology
As old-growth forest ecosystems become increasingly scarce in North America, the need to accurately and efficiently survey old-growth specialists and keystone species, such as the Pileated Woodpecker ( Dryocopus pileatus ), becomes increasingly important.
Austin C Zeller, Erin M Bayne, C. Lisa Mahon   +2 more
doaj   +1 more source

Detection error influences both temporal seroprevalence predictions and risk factors associations in wildlife disease models

Ecology and Evolution, 2019
Understanding the prevalence of pathogens in invasive species is essential to guide efforts to prevent transmission to agricultural animals, wildlife, and humans. Pathogen prevalence can be difficult to estimate for wild species due to imperfect sampling
Michael A. Tabak, Kerri Pedersen, Ryan S. Miller   +2 more
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Estimating detection rates and probabilities. [PDF]

, 2015
Abstract Surveillance activities provide only imperfect detection of biosecurity threats, and so quantifying detection rates and probabilities is important for making reliable inferences from survey data. Furthermore, an understanding of detection rates and probabilities allows for effective survey design and resource allocation to address ...
HAUSER, CE, Garrard, GE, Moore, JL
openaire   +2 more sources

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

The risks of learning: confounding detection and demographic trend when using count‐based indices for population monitoring

Ecology and Evolution, 2014
Theory recognizes that a treatment of the detection process is required to avoid producing biased estimates of population rate of change. Still, one of three monitoring programmes on animal or plant populations is focused on simply counting individuals ...
Vincenzo Gervasi, Henrik Brøseth, Olivier Gimenez, Erlend B. Nilsen, John D. C. Linnell   +4 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Paired sampling standardizes point count data from humans and acoustic recorders

Avian Conservation and Ecology, 2017
Acoustic recordings are increasingly used to quantify occupancy and abundance in avian monitoring and research. The recent development of relatively inexpensive programmable autonomous recording units (ARUs) has further increased the utility of acoustic ...
Steven L. Van Wilgenburg, Péter Sólymos, Kevin J. Kardynal, Matthew D. Frey   +3 more
doaj   +1 more source