Results 161 to 170 of about 913,709 (314)

Robust Control for the Detection Threshold of CFAR Process in Cluttered Environments. [PDF]

Sensors (Basel), 2020
Shin JH, Choi Y.
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source

CopyDetective: Detection threshold-aware copy number variant calling in whole-exome sequencing data. [PDF]

Gigascience, 2020
Sandmann S, Wöste M, de Graaf AO, Burkhardt B, Jansen JH, Dugas M.   +5 more
europepmc   +1 more source

An adaptive threshold neural-network scheme for rotorcraft UAV sensor failure diagnosis [PDF]

, 2007
This paper presents an adaptive threshold neural-network scheme for Rotorcraft Unmanned Aerial Vehicle (RUAV) sensor failure diagnosis. The approach based on adaptive threshold has the advantages of better detection and identification ability compared ...
Qi JT(齐俊桐), Zhao XG(赵新刚), Jiang Z(姜哲), Han JD(韩建达)   +3 more
core  

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Effect of level on spectral-ripple detection threshold for listeners with normal hearing and hearing loss. [PDF]

J Acoust Soc Am, 2020
Jorgensen EJ, McCreery RW, Kirby BJ, Brennan M.   +3 more
europepmc   +1 more source

Low complexity Erasure Insertion in RS-Coded SFH Spread-Spectrum Communications with Partial-Band Interference and Nakagami-$m$ Fading [PDF]

, 2002
—In this paper we propose two novel low-complexity, low-delay erasure insertion schemes, namely, the output threshold test (OTT) and joint maximum output and ratio threshold Test (MO-RTT). The employment of the OTT and MO-RTT is beneficial in the context
Yang, Lie-Liang, Hanzo, Lajos
core  

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source