Results 91 to 100 of about 553,105 (269)

Toward least-privilege isolation for software [PDF]

open access: yes, 2009
Hackers leverage software vulnerabilities to disclose, tamper with, or destroy sensitive data. To protect sensitive data, programmers can adhere to the principle of least-privilege, which entails giving software the minimal privilege it needs to ...
Bittau, A., Andrea Bittau
core  

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

open access: yesMolecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira   +7 more
wiley   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

open access: yesMolecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault   +12 more
wiley   +1 more source

Valid randomization.

open access: yes, 1987
Sufficient combinatorial conditions for weak and strong validity of randomization are well known for some common classes of designs with single error strata.
Bailey, Rosemary Anne   +2 more
core  

Moving Detector Quantum Walk with Random Relocation

open access: yes
We study a discrete-time quantum walk in presence of a detector at $x_D$ initially. The detector here is repeatedly removed after a span of $t_R$, the removal time, and reinserted at random locations. Two relocation rules are considered here: In Model~1, the detector is reinserted at any site beyond $x_D$, while in Model~2, reinsertion is done within a
Md Aquib Molla, Sanchari Goswami
openaire   +2 more sources

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

open access: yesFEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj   +3 more
wiley   +1 more source

Restricted randomization

open access: yes, 1983
A method of restricted randomization is given suitable for any block structure in which the number of levels of each block factor is a prime power. Under the assumption that all blocks are linear, certain patterns are designated undesirable, and initial ...
Bailey, Rosemary Anne, Bailey, R. A.
core  

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

open access: yesFEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill   +4 more
wiley   +1 more source

Exploiting correlation in the construction of D-optimal response surface designs. [PDF]

open access: yes
Cost considerations and difficulties in performing completely randomized experiments often dictate the necessity to run response surface experiments in a bi-randomization format.
Goos, Peter, Vandebroek, Martina
core  

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