Results 111 to 120 of about 153,059 (235)

Glucuronolactone Promotes Mucin Sulfation to Alleviate Deoxynivalenol‐Induced Intestinal Injury via Microbiota‐Dependent and ‐Independent AHR Activation

Advanced Science, EarlyView.
Glucuronolactone (GLU) as a natural metabolite of glucose, increases Lactobacillus amylovorus abundance and luminal IAA level to activate AHR signaling. In addition, GLU itself can directly elevate AHR signaling activity independently of microbiota and IAA.
Chenbin Cui, Beibei Zhang, Jiaxi Tang, Jing Hou, Yueqin Qiu, Kaiguo Gao, Li Wang, Zongyong Jiang, Xuefen Yang   +8 more
wiley   +1 more source

Lactylation Reprogramming in the Bone Infection Microenvironment Identifies PGK1 K361 as a Potential Therapeutic Target for Osteogenic Dysfunction

Advanced Science, EarlyView.
Staphylococcus aureus (S. aureus) infection creates a high‐lactate microenvironment, promoting p300‐mediated lactylation of PGK1 at lysine 361 (K361). Lactylated PGK1 translocates to the mitochondrial outer membrane and interacts with VDAC3. This interaction triggers FtMt downregulation, iron accumulation, and excessive PINK1/Parkin‐mediated mitophagy,
Han‐jun Qin, Si‐ying He, Ting‐hui Xiao, Da‐mao Dai, Xin‐jia Hu, Nan Jiang   +5 more
wiley   +1 more source

Ferroptosis: The Demise of Cells Through Phospholipid Peroxidation

Advanced Science, EarlyView.
The relative abundance of peroxidation‐resistant monounsaturated fatty acids (MUFAs) vs. peroxidation‐sensitive polyunsaturated fatty acids (PUFAs) incorporated into phospholipid (PL) is a key determinant of ferroptosis sensitivity, as the peroxidation of PL PUFA acyl chains (PUFA‐PL) disrupts membrane integrity, causing ferroptotic cell death ...
Shaojie Cui, Jin Ye
wiley   +1 more source

Nanozymes for Liver Disease Therapy: Advances in Catalytic Activity, Targeting Strategies, and Clinical Translation

Advanced Science, EarlyView.
Nanozymes, as enzyme‐mimicking nanomaterials, exhibit unique catalytic properties for the treatment of liver diseases. By regulating redox homeostasis, modulating immune responses, and enabling targeted delivery, nanozymes overcome the limitations of natural enzymes.
Xiandi Meng, Ge Zhu, Siyu Sun, Wenbo Yao, Yuning Zhang, Yong‐Guang Yang, Tianmeng Sun   +6 more
wiley   +1 more source

Chemical Proteomics Identifies Ketogenesis‐Mediated Cysteine Modifications Regulating Redox Function

Angewandte Chemie, EarlyView.
Herein, we report ketone body induce cysteine modifications beyond lysine acylation, as revealed by integrating chemical proteomics with open‐search methods. Among the modifications, cysteine crotonation (Ccr) was chemically validated by endogenous peptide‐based co‐elution assays.
Yuan‐Fei Zhou, Ling Zhang, Zhuoyi L. Niu, Xin Wang, Alejandro Storper, Ryan Hunt, Yingming Zhao, Nima Sharifi, Zhipeng A. Wang   +8 more
wiley   +2 more sources

Shaped by context: Evolutionary trajectories of desiccation tolerance in land plants

American Journal of Botany, EarlyView.
Abstract Desiccation tolerance (DT), the ability to survive near‐complete cellular dehydration, is widespread in diaspores but rare in the vegetative tissues of land plants. The patchy and punctuated phylogenetic distribution of vegetative desiccation tolerance (VDT) suggests that the trait is both ancient and recurrent, yet the evolutionary ...
Rose A. Marks, R. Shawn Abrahams, Jenna T. B. Ekwealor   +2 more
wiley   +1 more source

A community‐driven approach to address substance use and create a Great Plains American Indian addiction and recovery research agenda

American Journal of Community Psychology, EarlyView.
Abstract Substance use, specifically opioid and methamphetamine use, is of increasing concern among American Indian (AI) populations in the Great Plains. This community‐driven participatory study investigated the impacts of substance use and community‐defined needs in treating addiction.
Brynn Luger, Anna Kihlström, Brinda Sivaramakrishnan, Allison Kelliher, Frankie Kropp, Carmen Rosa, T. John Winhusen, Donald Warne, the CTN0129 participating Tribal communities   +8 more
wiley   +1 more source

Uncovering Cystic Fibrosis Carrier: Insights From a Heterozygous CFTR‐F508del Rabbit Model

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Chronic rhinosinusitis (CRS) is a heterogeneous inflammatory disorder frequently associated with impaired mucociliary clearance and bacterial infection. Individuals carrying a single cystic fibrosis transmembrane conductance regulator (CFTR) mutation exhibit partial CFTR dysfunction and are increasingly recognized as being at risk ...
Do‐Yeon Cho, Alexis E. McFeely, Daniel Skinner, Shaoyan Zhang, Justin Hedvat, Weslee Ping‐ay, Daniel M. Beswick, Justin H. Turner, Bradford A. Woodworth, Jie Xu   +9 more
wiley   +1 more source

Zebrafish and CRISPR—A synergistic approach to decipher and cure human diseases

Animal Models and Experimental Medicine, EarlyView.
Zebrafish, with high genetic homology to humans, serves as a powerful vertebrate model for disease modeling and drug discovery. Integration of CRISPR/Cas9 technology enables precise genome editing, facilitating the development of translational models for human diseases.
Manikandan Sivaprakasam, Aashika Raagavi Jeanpierre, Salma Mohammed, Rajesh Srinivasan, Aman Kumar Mohanty   +4 more
wiley   +1 more source

A comprehensive proteome and phosphoproteome atlas across nine organs of the Chinese hamster

Animal Models and Experimental Medicine, EarlyView.
This study presents the first comprehensive proteome and phosphoproteome atlas of the Chinese hamster across nine organs (heart, liver, lung, kidney, spleen, cerebral cortex, skeletal muscle, stomach, and testis or ovary). A total of 14 219 proteins were identified in the proteome, with 11 828 phosphorylated proteins and 47 122 phosphorylation sites ...
Luyao Zhang, Tao Ding, Wanjun Peng, Jie Kong, Xiaoyue Tang, Jiyu Xu, Qiaochu Wang, Zhiyi Zhang, Chunmei Shi, Yizhuo Tian, Huilan Yang, Yehong Yang, Yue Wu, Xiaoyan Liu, Jiangfeng Liu, Juntao Yang   +15 more
wiley   +1 more source