Results 101 to 110 of about 27,265 (285)

Targeting the deubiquitinase USP7 for degradation with PROTACs.

Chemical Communications, 2022
Targeting deubiquitinating enzymes (DUBs) has emerged as a promising therapeutic approach in several human cancers and other diseases. DUB inhibitors are exciting pharmacological tools but often exhibit limited cellular potency.
Arunima Murgai, Izidor Sosič, Martina Gobec, Patricia Lemnitzer, M. Proj, Sophie Wittenburg, Rabea Voget, M. Gütschow, J. Krönke, C. Steinebach   +9 more
semanticscholar   +1 more source

Cleavage‐Resistant CYLD Protects Against Autoimmune Hepatitis

Advanced Science, EarlyView.
Proteolytic cleavage of the deubiquitinase CYLD emerges as a critical driver of autoimmune hepatitis. TNFα‐induced CYLD loss in macrophages amplifies S100A9‐triggered MAPK activation, leading to excessive chemokine production and hepatic inflammation. Pharmacological inhibition of MEK signaling effectively attenuates experimental disease, highlighting ...
Han Liu, Chen Su, Jianling Liu, Mingyan Xing, Xiaoxia Wu, Lingxia Wang, Xiaoming Zhao, Hanwen Zhang, YangYang Xie, YangYang Wang, Hong Li, Yu Li, Ming Li, Haibing Zhang   +13 more
wiley   +1 more source

USP20 competitively binds to STUB1 to enhance CTSL expression and promote epithelial‐mesenchymal transition in head and neck squamous cell carcinoma

Clinical and Translational Medicine
Rationale Metastatic head and neck squamous cell carcinoma (mHNSCC) poses a significant threat to patient survival. Previous studies have identified cathepsin L (CTSL) as a key driver of tumourigenesis, metastasis and chemoresistance.
Lunhua Guo, Baihui Zhang, Xiaoqiao Cui, Xueying Wang, Jiaqing Xiao, Susheng Miao, Kaibin Song, Ji Sun   +7 more
doaj   +1 more source

Palmitoylation‐Mediated Ubiquitination of SRPK1 Regulates Ferroptosis in High‐Fat‐Induced Erectile Dysfunction

Advanced Science, EarlyView.
Elevated exogenous palmitic acid promotes the S‐palmitoylation of SRPK1 in endothelial cells, a dynamic process governed by ZDHHC24 and APT1. This post‐translational modification strengthens the interaction between SRPK1 and the E3 ubiquitin ligase MIB1, thereby facilitating the proteasomal degradation of SRPK1.
Xiao‐Hui Tan, Ke‐Fan Li, Yi‐Ming Yuan, Man‐Cheng Xia, Fang‐Zhou Zhao, Hong‐Gang Ying, Zhuo Zhou, Peng‐Chao Gao, Guo‐Qing Xie, Xue‐Song Li, Hui Jiang, Rui‐Li Guan   +11 more
wiley   +1 more source

Hypoxia activates IKK-NF-κB and the immune response in Drosophila melanogaster [PDF]

, 2014
Hypoxia, or low oxygen availability, is an important physiological and pathological stimulus for multicellular organisms. Molecularly, hypoxia activates a transcriptional programme directed at restoration of oxygen homoeostasis and cellular survival.
An, Azad, Bartels, Bonello, Centanin, Culver, Cummins, Cummins, Daniel Bandarra, Dekanty, Fandrey, Fu, Glittenberg, H. Arno Muller, Harhaj, Hetru, Jiang, John Biddlestone, Jono, Kenneth, Kounatidis, Lando, Lavista-Llanos, Liu, Lu, Massoumi, Melvin, Moniz, Perkins, Perkins, Ratcliffe, Rius, Rocha, Romero, Ruland, Scholz, Semenza, Sharon Mudie, Silke, Silverman, Silverman, Sonia Rocha, Sonnenfeld, Tornatore, Tsichritzis, van Uden, van Uden, Walmsley, Xue   +48 more
core   +5 more sources

Deubiquitinase USP20 promotes breast cancer metastasis by stabilizing SNAI2

Genes & Development, 2020
In this study, Li et al. conducted comprehensive gain- and loss-of-function screens using a human DUB cDNA library of 65 genes and an siRNA library of 98 genes, and identified USP20 as a deubiquitinase (DUB) that regulates a metastasis-promoting ...
Wenyang Li, Minhong Shen, Yizhou Jiang, Ruina Zhang, Hanqiu Zheng, Yong Wei, Z. Shao, Yibin Kang   +7 more
semanticscholar   +1 more source

DRJAMM Is Involved in the Oxidative Resistance in Deinococcus radiodurans

Frontiers in Microbiology, 2022
Proteins containing JAB1/MPN/MOV34 metalloenzyme (JAMM/MPN+) domains that have Zn2+-dependent deubiquitinase (DUB) activity are ubiquitous across among all domains of life.
Jianling Cai, Chaoming Pan, Ye Zhao, Hong Xu, Bing Tian, Liangyan Wang, Yuejin Hua   +6 more
doaj   +1 more source

Molecular basis of Lys11-polyubiquitin specificity in the deubiquitinase Cezanne [PDF]

, 2016
The post-translational modification of proteins with polyubiquitin regulates virtually all aspects of cell biology. Eight distinct chain linkage types in polyubiquitin co-exist and are independently regulated in cells.
A Borodovsky, A Bremm, A Bremm, A Luong, AJ McCoy, Bianca D. M. van Tol, C Vonrhein, D Komander, D Komander, David Komander, F Pareja, Farid El Oualid, G Bricogne, GH Pham, H Hu, H Hu, H Tran, Huib Ovaa, IE Wertz, J Jin, JC Christianson, JDF Licchesi, John E. Burke, K Enesa, K Keusekotten, KE Wickliffe, Malte Gersch, Masato Akutsu, Masato Kawasaki, MK Hospenthal, Monique P.C. Mulder, MPC Mulder, NS Berrow, P Emsley, P Evans, Paul P. Geurink, Paul R. Elliott, PD Adams, PP Geurink, PP Geurink, PR Evans, R Ekkebus, R Wiener, R Wiener, S Faggiano, S Moniz, S Vijay-Kumar, S-C Lin, Sarah L. Maslen, SG Hymowitz, Stefan M.V. Freund, TE Messick, TET Mevissen, TGG Battye, Tycho E. T. Mevissen, W Kabsch, Y-C Juang, Yogesh Kulathu   +57 more
core   +2 more sources

Deubiquitinase JOSD2 stabilizes YAP/TAZ to promote cholangiocarcinoma progression

Acta Pharmaceutica Sinica B, 2021
Cholangiocarcinoma (CCA) has emerged as an intractable cancer with scanty therapeutic regimens. The aberrant activation of Yes-associated protein (YAP) and transcriptional co-activator with PDZ-binding motif (TAZ) are reported to be common in CCA ...
Mei-jia Qian, Fangjie Yan, Wei-hua Wang, Jiamin Du, T. Yuan, Ruilin Wu, Chen-xi Zhao, Jiao-chen Wang, Jiabin Lu, Bo Zhang, Nengming Lin, Xin Dong, Xiaoyang Dai, Xiaowu Dong, Bo Yang, Hong Zhu, Qiaojun He   +16 more
semanticscholar   +1 more source

OTUD6A in Airway Epithelial Cells Exacerbates Allergic Asthma by Promoting Airway Inflammation and Airway Remodeling Through Deubiquitination of hResistin/mRELMα

Advanced Science, EarlyView.
This study elucidates a novel mechanistic role of the deubiquitinase OTUD6A in asthma pathogenesis, uncovering its regulatory function in airway inflammation and airway remodeling through the stabilization of hResistin/mRELMα. This study offers a novel regulatory axis (OTUD6A‐hResistin/mRELMα) in asthma pathogenesis and OTUD6A inhibition as a potential
Weiting Pan, Xinru Xi, Wei Dai, Tingfang Xiao, Yeqing Chen, Xuanyu Chen, Xiangting Ge, Chengguang Zhao, Hui Zhang, Yali Zhang, Weixi Zhang   +10 more
wiley   +1 more source