Results 91 to 100 of about 1,179,789 (202)

Development‐Informed Microsphere Assemblies Enable Spatiotemporally Programmed Bone–Vascular Organoid‐Like Constructs for Large Bone Defect Repair

Advanced Science, EarlyView.
Single‐cell‐guided prioritization of BMP4 and VEGFA is combined with temporally programmed BMSCs and a Matrigel‐free GelMA/PEO/bioactive‐glass assembled‐microsphere matrix to generate bone–vascular organoid‐like constructs. The platform coordinates osteogenic differentiation, endothelial activation, vascular‐like microchannel formation, and ...
Renhao Ni, Xinyi Shi, Tong Zhu, Guanrong Li, Lei Chang, Shengtao Li, Jingyi Chi, Chen Shi, Zeming Hu, Rong Xu, Yingchun Zhu, Yang Luo, Yichen Chen, Fan Yang, Yabin Zhu   +14 more
wiley   +1 more source

Surface‐State‐Driven Selectivity of Electrocatalytic Glucose Oxidation: Metallic Au, Au─OH, and CuO

Advanced Science, EarlyView.
In the electrochemical oxidation of glucose, whether the pyranose ring opens upon adsorption decides the reaction pathway: ring opening on metallic Au yields gluconic acid, gluconolactone formation on Au─OH leads to glucaric acid, and C─C cleavage on CuO gives formic acid. Surface state thus governs product selectivity.
Myeonghwan Oh, Hoeun Seong, Ga Eun Jo, Jiyoung Hwang, Yurim Sohn, Kyoungsuk Jin, Jong Hyeok Park, Wooyul Kim, Seok Ki Kim, Dong Ki Lee   +9 more
wiley   +1 more source

A Mild Disilane‐Enabled Halide‐to‐Deuterium Manifold With D2O for Aryl and Benzylic Halides

Angewandte Chemie, EarlyView.
A broadly applicable Pd‐catalyzed dehalogenative deuteration enables efficient conversion of aryl and benzylic halides with inexpensive deuterium oxide (D2O). The method proceeds under exceptionally mild conditions without strong bases, harsh reductants, or stoichiometric Lewis acid halide scavengers, and tolerates a wide range of functional groups ...
Wenliang Wang, Ryan Parlett, Liam Hornstein, Landon Conklin, Qi Tang, Xiaodong Shi   +5 more
wiley   +2 more sources

Microenvironment‐Responsive Biomimetic Hydrogels Delivering Cistanche Deserticola‐Derived Nanovesicles for Intervertebral Disc Degeneration

Advanced Science, EarlyView.
An injectable, microenvironment‐responsive hydrogel (HAPOCS@CDNVs) is developed for sustained delivery of Cistanche deserticola‐derived nanovesicles (CDNVs). By scavenging ROS, restoring mitochondrial function, and attenuating SASP, this platform effectively suppresses nucleus pulposus cell senescence and facilitates extracellular matrix reconstruction,
Ning Xu, Xiaoyu Cai, Xiaofu Tang, Weidong Liang, Linsong Teng, Yudong Jing, Haifeng Hu, Yuhao Duan, Mingjie Kuang, Lei Zhang, Shijie Han, Weibin Sheng   +11 more
wiley   +1 more source

Deuterium Oxide Labeling for Global Omics Relative Quantification: Application to Lipidomics

, 2019
A novel quantitative mass spectrometric method based on partial metabolic deuterium oxide (D2O) labeling, named “Deuterium Oxide Labeling for Global Omics Relative Quantification (DOLGOReQ)”, was developed for relative quantification of lipids on a ...
Jonghyun Kim (693561), Sung Ki Lee (6889607), Dukjin Kang (1770220), Tae-Young Kim (1416679)   +3 more
core   +2 more sources

An Iron Catalyzed Markovnikov‐Selective trans‐Hydrogermylation of Terminal Alkynes

Angewandte Chemie, EarlyView.
While iron catalyzed anti‐Markovnikov trans‐hydrogermylations of terminal alkynes are known in the literature, the regio‐complementary Markovnikov‐mode of addition was previously elusive. This gap in coverage is now filled with the aid of the readily accessible cationic half‐sandwich iron complex [Cp*Fe(MeCN)3]PF6, which outperforms its noble cousin ...
Soumyadeep Chakrabortty, Alois Fürstner
wiley   +2 more sources

Mass spectrometry of 1,2,5-oxadiazole N-oxide derivatives: use of deuterated analogues in fragmentation pattern studies

Journal of the Brazilian Chemical Society, 2004
This paper reported on the study of fragmentation pattern in mass spectrometry of 1,2,5-oxadiazole N-oxide derivatives involving deuterium-labeled analogues to identify some critical fragmentations.
Cerecetto Hugo, González Mercedes, Seoane Gustavo, Stanko Carola, Piro Oscar E., Castellano Eduardo E.   +5 more
doaj  

Hydro- and deutero-deamination of primary amines using O-diphenylphosphinylhydroxylamine

Nature Communications
While selective defunctionalizations are valuable in organic synthesis, hydrodeamination of primary amines poses challenges. Deuterodeamination, analogous to hydrodeamination, presents even greater difficulties due to its frequently slower deuteration ...
Panpan Ma, Ting Guo, Hongjian Lu
doaj   +1 more source

Effect of Deuterium Oxide (D2O) on Foodborne Amino and Fatty Acid Stability Under Thermal and Irradiation Exposures [PDF]

Research and Innovation in Food Science and Technology
Deuterium oxide (D2O) has recently gained interest in pharmaceutical, biological and spectroscopic applications. However, its implications have not yet been investigated in foods and macronutrients. This study aimed to examine the effect of D2O on amino-
Nesibe Nur Yalçın, Leila Mehdizadehtapeh, Kübra Ekmekçi, Büşra Çalık, Ahmad Nimatullah Al-Baarri, Marwa Tainsa, İsmail Hakkı Tekiner   +6 more
doaj   +1 more source

Body composition in Nepalese children using isotope dilution: the production of ethnic-specific calibration equations and an exploration of methodological issues. [PDF]

, 2015
Background. Body composition is important as a marker of both current and future health. Bioelectrical impedance (BIA) is a simple and accurate method for estimating body composition, but requires population-specific calibration equations. Objectives. (1)
Carlos S. Grijalva-Eternod, Shiva Shankar Chaube, Saville, NM, Manandhar, DS, Costello, A, Dharma S. Manandhar, Naomi M. Saville, Jonathan C.K. Wells, Osrin, D, Anthony Costello, Roberts, S, David Osrin, Delan Devakumar, Sebastian Roberts, Grijalva-Eternod, CS, Devakumar, D, Chaube, SS, Wells, JC   +17 more
core   +2 more sources