Results 81 to 90 of about 15,726 (247)

The liver‐brain axis: A multidimensional regulatory network implicated in Alzheimer's disease pathogenesis and clinical implications

Animal Models and Experimental Medicine, EarlyView.
Schematic diagram of the core pathways of the liver‐brain axis in regulating AD. The liver regulates cerebral Aβ deposition, tau phosphorylation, and neuroinflammation through pathways such as metabolic detoxification (urea cycle, ketone body metabolism, glutathione antioxidant system), molecular secretion (APOE, CRP, FGF21, IGF‐1), and Aβ clearance ...
Ning Zhang, Wei Chen, Meng Wang
wiley   +1 more source

Photochemical Ring Opening of Cyclopropyl Silyl Ethers Enables β–β Coupling, Radical‐Polar Crossover and Annulation

Angewandte Chemie, EarlyView.
A photochemical platform enables β–β coupling of cyclopropyl silyl ethers with electron‐deficient alkenes. The resulting adducts serve as entry points into annulative and radical–polar crossover pathways, providing rapid access to fused, bridged, and spirocyclic architectures, including late‐stage scaffold diversification to diterpene‐like carbocyclic ...
Jacop Rydén, Eilidh Young, Wilma Olsson, Eskil Flodén, Mattias Tan, Sebastian Clementson   +5 more
wiley   +2 more sources

Insights from quasi-in situ cryogenic-transfer atom probe tomography for analyzing hydrogen diffusion in metallic alloys

npj Materials Degradation
Understanding hydrogen embrittlement mechanisms requires insights into nanoscale hydrogen isotope segregation in materials. Cryogenic-transfer atom probe tomography (APT) can provide this insight, if the sample exposure is precisely controlled. Therefore,
Venkata Bhuvaneswari Vukkum, Zehao Li, Jack R. Grimm, Semanti Mukhopadhyay, Tingkun Liu, Vaithiyalingam Shutthanandan, Arun Devaraj   +6 more
doaj   +1 more source

Deuterated water (2H2O, heavy water) labelling to investigate human cell dynamics in vivo - lessons in protocol design and toxicity from the current literature

Frontiers in Immunology
The use of deuterated water (also known as ‘heavy water’) as a tracer to measure human in vivo cell proliferation rates for specific cell subsets has expanded significantly in recent years.
Ami Song, Yan Zhang, Robert Busch, Becca Asquith, Derek Macallan, Derek Macallan   +5 more
doaj   +1 more source

Simple and User-Friendly Methodology for Crystal Water Determination by Quantitative Proton NMR Spectroscopy in Deuterium Oxide. [PDF]

Anal Chem, 2023
Tynkkynen T, Vassaki M, Tiihonen TE, Lehto VP, Demadis KD, Turhanen PA.   +5 more
europepmc   +1 more source

Water, Alcohols, Amines, and Amides as Formal Hydrogen‐Atom‐Transfer Reagents Through Activation With Redox‐Active Lewis Acids

Angewandte Chemie, EarlyView.
Protic molecules containing strong O─H or N─H bonds typically resist hydrogen‐atom abstraction because of the high reactivity of the resulting heteroatom‐centered radicals. However, association of the protic molecules with redox‐active Lewis acids can provide powerful hydrogen‐atom donors or proton‐coupled‐electron‐transfer reagents.
Petra Vojáčková, Armido Studer
wiley   +2 more sources

Proteomics and lipids of lipoproteins isolated at low salt concentrations in D2O/sucrose or in KBr

Journal of Lipid Research, 2008
There is much interest in the significance of apolipoproteins and proteins that are noncovalently associated with lipoproteins. It is possible that the high ionic strength used for isolation of lipoproteins with KBr and NaI could alter the pattern of ...
Marcus Ståhlman, Pia Davidsson, Ida Kanmert, Birgitta Rosengren, Jan Borén, Björn Fagerberg, Germán Camejo   +6 more
doaj   +1 more source

Benzylic deuteration of alkylnitroaromatics via amine-base catalysed exchange with deuterium oxide. [PDF]

J Labelled Comp Radiopharm, 2023
Maddocks S, Samuri NF, Ridge K, Cunningham ID, Lockley WJS, Lockley WJS.   +5 more
europepmc   +1 more source

Borylcyclopropanes: Synthetic Strategies and Applications

Angewandte Chemie, EarlyView.
Borylcyclopropanes (cyclopropanes bearing a boron substituent) sit at the intersection of two privileged frameworks in synthesis. This review provides the first exhaustive survey of their chemistry, spanning metal–carbene, nucleophilic cyclization, radical, hydroboration, and C─H activation routes, and documenting applications in medicinal chemistry ...
Aiza A. Butt, Joseph M. Ready
wiley   +2 more sources

Effects of variations in atmospheric temperature and humidity on the estimation of exclusive breastfeeding status using the deuterium oxide dose-to-mother technique. [PDF]

Front Pediatr, 2023
Baby J, Kaestel P, Preston T, Duffull SB, Liu Z, Diana A, Houghton L, Kurpad AV, Thomas T.   +8 more
europepmc   +1 more source