Results 171 to 180 of about 38,233 (200)

Carbohydrate‐Based Drug Discovery: Synthetic Strategies and Clinical Applications

Israel Journal of Chemistry, Volume 66, Issue 3, May 2026.
The picture depicts the molecules discussed in the review. On the left side, the general scaffold of sugars is shown. Next to it are four carbohydrate‐based molecules, including remdesivir, islatravir, empagliflozin, and Globo‐H. Remdesivir and islatravir contain a substituted ribose ring attached to a modified nucleobase.
Stephan Scheeff, Jemma Arakelyan, Billy Wai‐Lung Ng   +2 more
wiley   +1 more source

New perspectives on the physiological basis of muscle loss

Experimental Physiology, EarlyView.
Alistair J. Monteyne, Marlou L. Dirks
wiley   +1 more source

Deuterium 1‐Channel Transmit/16‐Channel High Impedance Receive Array Combined With 16‐Channel 1H Dual‐Row Transceiver Array for 7 Tesla Brain Imaging

Magnetic Resonance in Medicine, Volume 95, Issue 5, Page 3021-3030, May 2026.
ABSTRACT Purpose To develop and evaluate an 2H/1H coil configuration that enables deuterium metabolic imaging at 7 T while preserving high‐quality 1H anatomical imaging. Methods An 16‐channel 2H high‐impedance receive array was combined with a 2H transmit birdcage and a 16‐channel dual‐row 1H transceiver array.
Bei Zhang, Wenkai Liang, Chichen Dong, Anke Henning   +3 more
wiley   +1 more source

MicroRNA 15a and 16 Regulate Proteostasis in Non‐Small Cell Lung Cancer

FASEB BioAdvances, Volume 8, Issue 5, May 2026.
Overexpression of microRNA15a/16 slows rates of tumor growth and protein synthesis in cultured lung cancer cells. These co‐transcribed miRNAs target a wide array of anabolic and pro‐tumor processes, indicating their central role in regulating lung cancer cellular anabolism. ABSTRACT Aberrant anabolic activity is critical to tumor biology; however, much
Patrick J. Ryan, Bethany C. Guerra, Peter Nghiem, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +5 more
wiley   +1 more source

Advances and opportunities for computational interrogation of plant proteins

The Plant Journal, Volume 126, Issue 3, May 2026.
SUMMARY Plants exhibit remarkable biochemical and physiological diversity, and are capable of adapting to a wide range of environmental conditions and stresses. This complexity makes them essential systems for understanding how life responds to a changing climate.
Sarah M. Bohling, Shaila Musharoff, Laura H. Gunn   +2 more
wiley   +1 more source

Quantification and Localisation of New Brain Lipid Synthesis Using Deuterium Oxide and High Resolution Mass Spectrometry

Angewandte Chemie, Volume 138, Issue 18, 27 April 2026.
Liquid chromatography tandem mass spectrometry and mass spectrometry imaging were used in combination with deuterium oxide administration to quantify and localise newly synthesised myelin lipids in the mouse brain. This methodology, used here to show sites of myelin repair, enables the measurement of dynamic lipid synthesis in living systems and ...
Catherine Zhang, Jesse A. Michael, Jonathan D. Teo, Huitong Song, Mika T. Westerhausen, Shadrack M. Mutuku, Shane R. Ellis, Anthony S. Don   +7 more
wiley   +2 more sources

Liver‐Specific Suppression of PLA2G6/iPLA2β Improves Glucose and Lipid Metabolism in High‐Fat Diet‐Fed Mice

The FASEB Journal, Volume 40, Issue 8, 30 April 2026.
Liver‐specific suppression of PLA2G6/iPLA2β by utilizing the short‐hairpin RNA knockdown technique using an adenovirus vector (Ad‐shPLA2G6) altered phospholipid and fatty acid metabolites and suppressed hepatic lipid accumulation, serum triglyceride, and fasting glucose levels.
Kahori Shimizu, Mana Nishibata, Katsuyuki Nagata, Sho Hori, Shotaro Michinaga, Miyuki Kanehara, Miho Hashimoto‐Iwasaki, Fuminori Sakurai, Hideo Shindou, Koji Tomita, Toru Nishinaka, Hiroyuki Mizuguchi   +11 more
wiley   +1 more source

Structure and Dynamics of Imidazolium in an Ionic Liquid‐PEGDA Iongel via IR, 2D‐IR, and NMR Spectroscopy

ChemPhysChem, Volume 27, Issue 8, 28 April 2026.
Linear and nonlinear vibrational spectroscopies detect tight and loose complexes between imidazolium cations and poly(ethyleneoxide) chains in an iongel. Fourier transform infrared absorption spectroscopy, ultrafast two‐dimensional infrared spectroscopy, nuclear magnetic resonance spectroscopy, and density functional theory calculations show that, in ...
Kallol Mukherjee, Matthew R. Liberatore, Tyler A. Parrack, Sean Garrett‐Roe   +3 more
wiley   +1 more source

NiH‐Catalyzed Enantioconvergent α‐Alkenylation of Carbonyl Compounds via Markovnikov Alkyne Hydronickellation

Angewandte Chemie, Volume 138, Issue 17, 20 April 2026.
A NiH‐catalyzed α‐alkenylation via Markovnikov hydronickellation of alkynes enables convenient access to α‐chrial β‐methylene carbonyl frameworks that are prevalent in biorelevant molecules. High regio‐ and enantioselectivities have been achieved with excellent functional group tolerance and applicability toward complex structures. The β‐methylene unit
Hyeontaek Nam, Seji Jang, Dongwook Kim, Sangwon Seo   +3 more
wiley   +2 more sources

Rh‐Catalyzed Chemodivergent Parallel Kinetic Resolution and Desymmetrization of Enynes and Dienynes with Acrylamides

Angewandte Chemie, Volume 138, Issue 17, 20 April 2026.
Rh‐catalyzed chemodivergent parallel kinetic resolution of racemic 1,6‐enynes with α‐fluoroacrylamides or mixtures of different acrylamides proceeded via [2+2+2] cycloaddition and C–H alkylation to afford structurally and stereochemically distinct products with high selectivity under mild conditions.
Shintaro Hamada, Julong Jiang, Yu Sato, Takashi Yamazaki, Satoshi Maeda, Ken Tanaka   +5 more
wiley   +2 more sources