Results 21 to 30 of about 409,570 (285)

Vorstellung des Forschungsprojekts «INTERLOR - Lotharingien und das Papsttum. Interaktions-, Integrations- und Transformationsprozesse im Spannungsfeld zwischen zentraler Steuerung und regionaler Eigendynamik (11. - Anfang 13. Jahrhundert)»

Studi di Storia Medioevale e di Diplomatica: Nuova Serie, 2021
Der Text skizziert das mit dem Projekt «INTERLOR. Lotharingien und das Papsttum. Interaktions-, Integrations- und Transformationsprozesse im Spannungsfeld zwischen zentraler Steuerung und regionaler Eigendynamik (11. bis Anfang 13.
Harald Müller, Hannes Engl, Michel Margue, Timothy Salemme   +3 more
doaj   +1 more source

Guidelines for Safeguarding Good Research Practice. Code of Conduct

, 2022
The DFG´s Code of Conduct “Safeguarding Good Research Practice” represents the consensus among the member organisations of the DFG on the fundamental principles and standards of good practice and are upheld by these organisations.
Deutsche Forschungsgemeinschaft
core   +1 more source

Insights into IGH clonal evolution in BCP-ALL: frequency, mechanisms, associations, and diagnostic implications

Frontiers in Immunology, 2023
IntroductionThe malignant transformation leading to a maturation arrest in B-cell precursor acute lymphoblastic leukemia (BCP-ALL) occurs early in B-cell development, in a pro-B or pre-B cell, when somatic recombination of variable (V), diversity (D ...
Franziska Darzentas, Monika Szczepanowski, Michaela Kotrová, Alina Hartmann, Alina Hartmann, Alina Hartmann, Thomas Beder, Thomas Beder, Nicola Gökbuget, Stefan Schwartz, Stefan Schwartz, Lorenz Bastian, Lorenz Bastian, Lorenz Bastian, Claudia Dorothea Baldus, Claudia Dorothea Baldus, Claudia Dorothea Baldus, Karol Pál, Nikos Darzentas, Monika Brüggemann, Monika Brüggemann, Monika Brüggemann   +21 more
doaj   +1 more source

Data for "Machine learning-based sampling of virtual experiments within the full stress state"

, 2022
Data for "Machine learning-based sampling of virtual experiments within the full stress state" by Alexander Wessel, Lukas Morand, Alexander Butz, Dirk Helm and Wolfram Volk.The authors gratefully acknowledge funding from the Federal Ministry for Economic
Wessel, Alexander, Morand, Lukas, Helm, Dirk, Volk, Wolfram, Butz, Alexander   +4 more
core   +1 more source

Personality matters – The interplay between consistent individual differences and mouse welfare in female C57BL6/J mice

Frontiers in Animal Science
To ensure good welfare of animals in human hands, it is essential to modify housing conditions according to the animals’ needs. Traditionally, the effects of such modifications are studied by means of group-level comparisons, thereby widely neglecting ...
Marlene G. U. Sroka, Marlene G. U. Sroka, Oliver Ambree, Oliver Ambree, Celina Dohmen, Celina Dohmen, Rupert Palme, Sylvia Kaiser, Sylvia Kaiser, S. Helene Richter, S. Helene Richter   +10 more
doaj   +1 more source

Extension of CART using multiple splits under order restrictions [PDF]

, 2003
CART was introduced by Breiman et al. (1984) as a classification tool. It divides the whole sample recursively in two subpopulations by finding the best possible split with respect to a optimisation criterion.
Salanti, Georgia, Strobl, R., Salanti, G., Ulm, Kurt   +3 more
core   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source