Results 31 to 40 of about 77,988 (240)

Exploring the binding sites of VRT534 at Cx26 as a putative chemical chaperone for targeted treatment of hereditary hearing disorders

Frontiers in Medicine
Hearing loss is the most common sensory disorder, significantly affecting the quality of life for millions of people worldwide. Chemical chaperones are emerging as a potential therapeutic option for hereditary forms of deafness associated with protein ...
Jennifer Harre, Jennifer Harre, Dahua Wang, Athanasia Warnecke, Athanasia Warnecke, Carsten Zeilinger   +5 more
doaj   +1 more source

Electronic Resource Management System. Vernetzung von Lizenzinformationen

o-bib. Das offene Bibliotheksjournal, 2014
In den letzten zehn Jahren spielen elektronische Ressourcen im Bereich der Erwerbung eine zunehmend wichtige Rolle: Eindeutig lässt sich hier ein Wandel in den Bibliotheken (fort) vom reinen Printbestand zu immer größeren E-Only-Beständen feststellen ...
Michaela Selbach, Daniel Armin Rupp
doaj   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Lassen Sie uns über das Scheitern bei Projekten mit kommerziellen Partnern sprechen: Ein Interview mit Andreas Degkwitz

Bibliothek
Die Deutsche Forschungsgemeinschaft (DFG) und der Wissenschaftsrats (WR) haben 2011 den sechs deutschen Bibliotheksverbünden empfohlen, sich mit ihren Infrastrukturen auf zeitgemäße, überregionale Services auszurichten.
Degkwitz Andreas
doaj   +1 more source

Digitalisierung der vollständigen deutschsprachigen Zeitungen des 17. Jahrhunderts in der SuUB Bremen: Ein Werkstattbericht

o-bib. Das offene Bibliotheksjournal, 2014
Seit Mai 2013 fördert die Deutsche Forschungsgemeinschaft (DFG) Pilotprojekte zur Digitalisierung historischer Zeitungen in vier Bibliotheken Deutschlands, darunter in der Staats- und Universitätsbibliothek Bremen.
Maria Hermes, Maria Elisabeth Müller
doaj   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

An open chat with… Johannes Herrmann

FEBS Open Bio
Johannes Herrmann is a Professor of Cell Biology at the University of Kaiserslautern in Germany. His research focus is centred on the biogenesis of mitochondrial proteins.
Ioannis Tsagakis, Johannes Herrmann
doaj   +1 more source

Vascular occlusion by neutrophil extracellular traps in COVID-19

EBioMedicine, 2020
Background: Coronavirus induced disease 2019 (COVID-19) can be complicated by severe organ damage leading to dysfunction of the lungs and other organs. The processes that trigger organ damage in COVID-19 are incompletely understood. Methods: Samples were
Moritz Leppkes, Jasmin Knopf, Elisabeth Naschberger, Aylin Lindemann, Jeeshan Singh, Irmgard Herrmann, Michael Stürzl, Léonie Staats, Aparna Mahajan, Christine Schauer, Anita N. Kremer, Simon Völkl, Kerstin Amann, Katja Evert, Christina Falkeis, Andreas Wehrfritz, Ralf J. Rieker, Arndt Hartmann, Andreas E. Kremer, Markus F. Neurath, Luis E. Muñoz, Georg Schett, Martin Herrmann   +22 more
doaj   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Forschungsdatenmanagement in DFG-Sonderforschungsbereichen: Teilprojekte Informationsinfrastruktur (INF-Projekte)

Library Ideas, 2013
Seit 2007 gibt es im Rahmen von DFG-Sonderforschungsbereichen die Möglichkeit, ein „Teilprojekt Informationsinfrastruktur” (kurz: INF-Projekt) zu beantragen.
Claudia Engelhardt
doaj