Results 31 to 40 of about 409,570 (285)
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Pallas, 2016 The Mulomedicina of Teodorico di Cervia is centered in an interdisciplinary project which is actually applied for at the Deutsche Forschungsgemeinschaft (DFG). According to our preliminary work in the last years it can be stated that the editions of Dolz,
Martina Schwarzenberger
doaj +1 more source
Molecular Oncology, EarlyView.We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth +17 more
wiley +1 more source
Energy-momentum time integration of gradient-based models for fiber-bending stiffness in anisotropic thermo-viscoelastic continua [PDF]
, 2022 [EN] For our research, we are motivated by dynamic simulations of 3D fiber-reinforced materials in lightweight structures. In such materials, the material reinforcement is performed by fiber rovings with a separate bending stiffness, which can be ...
Dietzsch, Julian +2 more
core +1 more source
Molecular Oncology, EarlyView.Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu +9 more
wiley +1 more source
Emotions in Contexts: Cultural Conceptions in Ancient and Medieval Societies
Aestimatio: The papers in this special section derive, directly or indirectly, from a workshop on current methods and approaches in emotion research held at Johannes Gutenberg-Universität Mainz on 25–26 February 2019 in association with the tenure of a Mercator ...
Douglas Cairns
doaj +1 more source
Evaluation der Klinischen Forschungsgruppen. Abschlussbericht von inspire research im Auftrag der Deutschen Forschungsgemeinschaft (DFG) [PDF]
, 2022 Die Deutsche Forschungsgemeinschaft (DFG) fördert seit dem Jahr 2001 Klinische Forschungsgruppen (KFO) an hochschulmedizinischen Einrichtungen (HME).
Geyer, Anton
core +1 more source
RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells
FEBS Open Bio, EarlyView.RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour +2 more
wiley +1 more source
Frontiers in MedicineHearing loss is the most common sensory disorder, significantly affecting the quality of life for millions of people worldwide. Chemical chaperones are emerging as a potential therapeutic option for hereditary forms of deafness associated with protein ...
Jennifer Harre +5 more
doaj +1 more source