Results 91 to 100 of about 878,178 (411)

Trade policy in West Germany. [PDF]

Außenwirtschaftspolitik; Deutschland;
Heitger, Bernhard, Jüttemeier, Karl-Heinz, Kirkpatrick, Grant, Klepper, Gernot, Weiss, Frank Dietmar   +4 more
core  

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

Regulation of Water Supply in Germany [PDF]

Wasserversorgung, Privatisierung, Regulierung, Deutschland, Water supply, Privatization, Regulation ...
Britta Pielen, Colette de Roo, R. Andreas Kraemer   +2 more
core  

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

Molecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu, Dilara Demirci, Sude Eris, Bengisu Dayanc, Ece Cakiroglu, Merve Basol, Merve Uysal, Gulcin Cakan‐Akdogan, Fang Liu, Mehmet Ozturk, Gökhan Karakülah, Serif Senturk   +11 more
wiley   +1 more source

For a dual income tax [PDF]

Einkommensteuer, Unternehmensbesteuerung, Steuerreform, Deutschland, Income tax, Corporate taxation, Tax reform ...
Wolfgang Wiegard
core  

Multi‐omic characterization of consensus molecular subtype 1 (CMS1) colorectal cancer with dampened immune response improves precision medicine

Molecular Oncology, EarlyView.
This study highlights the importance of multi‐omic analyses in characterizing colorectal cancers. Indeed, our analysis revealed a rare CMS1 exhibiting dampened immune activation, including reduced PD‐1 expression, moderate CD8+ T‐cell infiltration, and suppressed JAK/STAT pathway.
Livia Concetti, Manuel Scimeca, Julia Bischof, Jonathan Woodsmith, Massimiliano Agostini, Cristina Fiorani, Yufang Shi, Eleonora Candi, Gerry Melino, Alessandro Mauriello, Giuseppe S. Sica   +10 more
wiley   +1 more source

Regulation of the Electricity Market in Germany [PDF]

Elektrizitätswirtschaft, Regulierung, Deutschland, Electric utility industry, Regulation ...
Volker Heck
core  

Präzisierter Lehrplan für Geschichte Klasse 7 : tritt am 1. September 1968 für den Unterricht in der allgemeinbildenden polytechnischen Oberschule in Kraft / Ministerrat d. Dt. Demokrat. Republik, Ministerium für Volksbildung [PDF]

, 2007
In der Klasse 7 ist den Schülern an Hand ausgewählter Ereignisse und Abläufe aus der Geschichte einiger Länder ein lebendiges Bild über die historische Entwicklung vom Ausgang des 15. Jahrhunderts bis zur Mitte des 19. Jahrhunderts zu vermitteln. Nachdem
Deutschland / Ministerium für Volksbildung
core  

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source

„Rücken“ kostet pro Jahr 11,6 Milliarden Euro

Monitor Versorgungsforschung
Mit den seit 2019 jährlich erscheinenden Gesundheitsatlas-Ausgaben des Wissenschaftlichen Instituts der AOK (WIdO) wird die Gesundheitssituation aller Einwohner:innen in den 400 Landkreisen und Städten Deutschlands transparent gemacht.
Peter Stegmaier
doaj   +1 more source