Results 121 to 130 of about 878,178 (411)

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

open access: yesMolecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu   +12 more
wiley   +1 more source

Money, interest rate spreads, and economic activity. [PDF]

open access: yes
Zinsstruktur; Geldmenge; Konjunkturprognose; Prognoseverfahren; Deutschland; Italien; Frankreich;
Sauer, Christine, Scheide, Joachim
core  

Evaluation of KRAS and NRAS mutations in metastatic colorectal cancer: an 8‐year study of 10 754 patients in Turkey

open access: yesMolecular Oncology, EarlyView.
This nationwide study evaluated KRAS and NRAS mutations in 10 754 Turkish patients with metastatic colorectal cancer. The results revealed a mutation frequency of 51.1%, with 46.6% having KRAS mutations, 4.5% having NRAS mutations, and 48.5% being wild‐type for both.
Gozde Kavgaci   +6 more
wiley   +1 more source

Deutschland

open access: yes, 1886
Umschau in Heimat und Fremde: ein geographisches Lesebuch zur Ergänzung der Lehrbücher der Geographie, insonderheit derer von Ernst v.
openaire   +3 more sources

TRPM8 levels determine tumor vulnerability to channel agonists

open access: yesMolecular Oncology, EarlyView.
TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo   +18 more
wiley   +1 more source

Nach 1995 deutliche Wachstumsschwäche der deutschen Wirtschaft im internationalen Vergleich [PDF]

open access: yes
Im Folgenden werden ausgewählte Ergebnisse einer neuen Datenquelle zur Messung von Wachstum und Produktivität im internationalen Vergleich präsentiert. Die Informationen decken den Zeitraum von 1970 bis 2004 ab.
Bernd Görzig, Martin Gornig
core  

The anticancer effect of the HDAC inhibitor belinostat is enhanced by inhibitors of Bcl‐xL or Mcl‐1 in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
The pan‐HDAC inhibitor belinostat increases the expression of the pro‐apoptotic proteins Bim, Puma, and Noxa and induces apoptosis in ovarian cancer cell lines and patient‐derived tumor organoids when used at high concentrations. Moreover, inhibiting the anti‐apoptotic proteins Bcl‐xL or Mcl‐1 sensitizes these preclinical models to the cytotoxic effect
Cécilia Thomine   +10 more
wiley   +1 more source

Können oder wollen sie nicht?

open access: yesMonitor Versorgungsforschung
Nahezu alle Fachleute sind sich darüber einig, dass das deutsche Gesundheitssystem an seine Grenzen gestoßen ist und umfassend überarbeitet werden muss. Zwar geben Versicherte und Steuerzahler sehr viel Geld für Gesundheitsversorgung aus, erhalten dafür ...
Dr. Dr. Klaus Piwernetz   +1 more
doaj   +1 more source

National Institutional Systems in Global Competition and the Inertia of German Labour Market Institutions [PDF]

open access: yes
Arbeitsverwaltung, Internationaler Wettbewerb, Deutschland, Welt, Labour administration, Global competition, Germany ...
Wolfgang Ochel
core  

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