Results 51 to 60 of about 14,908,548 (354)

A Short Review About Working Memory

Ankara Üniversitesi Tıp Fakültesi Mecmuası, 2021
The working memory system is responsible for the protection of limited information that can be kept in mind at once. Discussions on the existence of different circuits for different working memory, the limit of working memory and its developability are ...
Evrim Gökçe, Emel Güneş, Erhan Nalçacı   +2 more
doaj   +1 more source

Simultaneous affinity maturation and developability enhancement using natural liability-free CDRs

mAbs, 2022
Affinity maturation is often a necessary step for the development of potent therapeutic molecules. Many different diversification strategies have been used for antibody affinity maturation, including error-prone PCR, chain shuffling, and targeted ...
Andre A. R. Teixeira, Sara D’Angelo, M. Frank Erasmus, Camila Leal-Lopes, Fortunato Ferrara, Laura P. Spector, Leslie Naranjo, Esteban Molina, Tamara Max, Ashley DeAguero, Katherine Perea, Shaun Stewart, Rebecca A. Buonpane, Horacio G. Nastri, Andrew R. M. Bradbury   +14 more
doaj   +1 more source

De novo design of epitope-specific antibodies against soluble and multipass membrane proteins with high specificity, developability, and function

bioRxiv
We present JAM, a generative protein design system that enables fully computational design of antibodies with therapeutic-grade properties for the first time.
Surojit Biswas
semanticscholar   +1 more source

Approximation by mappings with singular Hessian minors

, 2017
Let $\Omega\subset\mathbb R^n$ be a Lipschitz domain.
Liu, Zhuomin, Malý, Jan, Pakzad, Mohammad Reza   +2 more
core   +1 more source

How can we discover developable antibody-based biotherapeutics?

Frontiers in Molecular Biosciences, 2023
Antibody-based biotherapeutics have emerged as a successful class of pharmaceuticals despite significant challenges and risks to their discovery and development.
Joschka Bauer, Joschka Bauer, Nandhini Rajagopal, Nandhini Rajagopal, Priyanka Gupta, Priyanka Gupta, Pankaj Gupta, Pankaj Gupta, Andrew E. Nixon, Sandeep Kumar, Sandeep Kumar   +10 more
doaj   +1 more source

Development of disulfide-stabilized Fabs for targeting of antibody-directed nanotherapeutics

mAbs, 2022
Antibody-directed nanotherapeutics (ADNs) represent a promising delivery platform for selective delivery of an encapsulated drug payload to the site of disease that improves the therapeutic index.
Melissa L. Geddie, Dmitri B. Kirpotin, Neeraj Kohli, Tad Kornaga, Bjoern Boll, Maja Razlog, Daryl C. Drummond, Alexey A. Lugovskoy   +7 more
doaj   +1 more source

Five computational developability guidelines for therapeutic antibody profiling

Proceedings of the National Academy of Sciences of the United States of America, 2019
Significance Immunogenicity, instability, self-association, high viscosity, polyspecificity, or poor expression can all preclude an antibody from becoming a therapeutic. Early identification of these negative characteristics is essential.
M. Raybould, Claire Marks, K. Krawczyk, Bruck Taddese, Jaroslaw Nowak, A. Lewis, A. Bujotzek, Jiye Shi, C. Deane   +8 more
semanticscholar   +1 more source

Aryl Phosphoramidates of 5-Phospho Erythronohydroxamic Acid, A New Class of Potent Trypanocidal Compounds [PDF]

, 2010
RNAi and enzymatic studies have shown the importance of 6-phosphogluconate dehydrogenase (6-PGDH) in Trypanosoma brucei for the parasite survival and make it an attractive drug target for the development of new treatments against human African ...
Alibu, Vincent P., Barrett, Michael P., Gilbert, Ian H., Norval, Suzanne, Read, Kevin D., Ruda, Gian Filippo, Wong, Pui Ee   +6 more
core   +4 more sources

Developing sustainable development [PDF]

WIT Transactions on Ecology and the Environment, 2008
Ralf Brand and Andrew Karvonen (The ecosystem of expertise: complementary knowledges for sustainable development. Sustainability: Science, Practice and Policy, 3(1), pp 21–31, Spring 2007) suggest that sustainability poses challenges to the discourse of technical experts and that many existing models do not fit with traditional disciplinary boundaries.
B. Tomkinson, C. Engel, R. Tomkinson, H. Dobson   +3 more
openaire   +1 more source

A Quality Improvement Initiative to Standardize Pneumocystis jirovecii Pneumonia Prophylaxis in Pediatric Patients With Solid Tumors

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Pediatric patients with extracranial solid tumors (ST) receiving chemotherapy are at an increased risk for Pneumocystis jirovecii pneumonia (PJP). However, evidence guiding prophylaxis practices in this population is limited. A PJP‐related fatality at our institution highlighted inconsistent prescribing approaches and concerns about
Kriti Kumar, Denise M. Connolly, Ellen Kellington, Elyse Zelunka, Karla Kerrigan, Furqan Shaikh, Paul C. Nathan, Meredith S. Irwin, Sarah Cohen‐Gogo   +8 more
wiley   +1 more source