Results 61 to 70 of about 14,908,548 (354)
Phage Display Libraries for Antibody Therapeutic Discovery and Development
Antibodies, 2019 Phage display technology has played a key role in the remarkable progress of discovering and optimizing antibodies for diverse applications, particularly antibody-based drugs.
Juan C. Almagro +3 more
doaj +1 more source
mAbs, 2023 A challenge when developing therapeutic antibodies is the identification of candidates with favorable pharmacokinetics (PK) early in development. A key determinant of immunoglobulin (IgG) serum half‑life in vivo is the efficiency of pH-dependent binding ...
Thomas Müller +6 more
semanticscholar +1 more source
Interactive procedural simulation of paper tearing with sound [PDF]
, 2015 International audienceWe present a phenomenological model for the real-time simulation of paper tearing and sound. The model uses as input rotations of the hand along with the index and thumb of left and right hands to drive the position and orientation
Blanc-Beyne, Thibault +7 more
core +4 more sources
Sickle Cell Disease Is an Inherent Risk for Asthma in a Sibling Comparison Study
Pediatric Blood &Cancer, EarlyView.ABSTRACT Introduction Sickle cell disease (SCD) and asthma share a complex relationship. Although estimates vary, asthma prevalence in children with SCD is believed to be comparable to or higher than the general population. Determining whether SCD confers an increased risk for asthma remains challenging due to overlapping symptoms and the ...
Suhei C. Zuleta De Bernardis +9 more
wiley +1 more source
mAbs, 2021 Therapeutic antibodies must have “drug-like” properties. These include high affinity and specificity for the intended target, biological activity, and additional characteristics now known as “developability properties”: long-term stability and resistance
Andre Azevedo Reis Teixeira +10 more
semanticscholar +1 more source
Statistical Mechanics of Developable Ribbons
, 2010 We investigate the statistical mechanics of long developable ribbons of finite width and very small thickness. The constraint of isometric deformations in these ribbon-like structures that follows from the geometric separation of scales introduces a ...
Giomi, L., Mahadevan, L.
core +1 more source
Screening a protein kinase inhibitor library against Plasmodium falciparum [PDF]
, 2017 Background Protein kinases have been shown to be key drug targets, especially in the area of oncology. It is of interest to explore the possibilities of protein kinases as a potential target class in Plasmodium spp., the causative agents of malaria ...
Baragana, Beatriz +12 more
core +2 more sources
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background While Wilms tumor (WT) typically has a favorable prognosis, relapsed cases—especially those with high‐risk histology—remain therapeutically challenging after intensive frontline therapy. The combination of vincristine and irinotecan has demonstrated activity in pediatric solid tumors, and pazopanib, a multi‐targeted tyrosine kinase ...
Maria Debora De Pasquale +6 more
wiley +1 more source
On the incompressibility of cylindrical origami patterns
, 2016 The art and science of folding intricate three-dimensional structures out of paper has occupied artists, designers, engineers, and mathematicians for decades, culminating in the design of deployable structures and mechanical metamaterials.
Bös, Friedrich +3 more
core +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT We sought to identify potential early risk biomarkers for lung disease in children post‐allogeneic HCT. Patients with pulmonary function tests 3 months post‐transplant and plasma samples between days 7 and 14 post‐HCT were included. Six of 27 subjects enrolled had reduced forced expiratory volume 1 (FEV1) z scores.
Isabella S. Small +3 more
wiley +1 more source