Results 81 to 90 of about 1,117 (238)

Biophysical Analysis of Therapeutic Antibodies in the Early Development Pipeline

Biologics: Targets & Therapy
Leon F Willis,1 Nikil Kapur,2 Sheena E Radford,1 David J Brockwell1 1School of Molecular and Cellular Biology, Astbury Centre for Structural Molecular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, LS2 9JT, UK; 2School of Mechanical
Willis LF, Kapur N, Radford SE, Brockwell DJ   +3 more
doaj  

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Macro- and Micro-Heterogeneity of Natural and Recombinant IgG Antibodies

Antibodies, 2019
Recombinant monoclonal antibodies (mAbs) intended for therapeutic usage are required to be thoroughly characterized, which has promoted an extensive effort towards the understanding of the structures and heterogeneity of this major class of molecules ...
Alain Beck, Hongcheng Liu
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

The Evolving Druggability and Developability Space: Chemically Modified New Modalities and Emerging Small Molecules

, 2020
Part one: This review provides a holistic introduction to the evolving druggability and developability space. Before the genomic era when traditional druggable targets were the main stream of drug discovery, Lipinski’s rule-of-five (Ro5) evolved and ...
Venkata R. Krishnamurthy, Manuel Sanchez-Felix, Phenil J. Patel, Mallick, Pankajini, Pankajini Mallick, Margaret Landis, Reid, Darren L., Prajakta Gadgil, Dipal Patel, Yang, Wenzhan, Gadgil, Prajakta, Sanchez-Felix, Manuel, Patel, Dipal, Darren L. Reid, Landis, Margaret, Patel, Phenil J., Wenzhan Yang   +16 more
core   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Developing The Cyclotactor

CoRR, 2009
Proceedings of the International Conference on New Interfaces for Musical Expression ...
openaire   +3 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Deep learning assessment of nativeness and pairing likelihood for antibody and nanobody design with AbNatiV2

mAbs
Most immune-system created antibodies balance good binding and stability with low toxicity and self-reactivity. Quantifying the nativeness of a candidate sequence – its likelihood of belonging to natural immune repertoires – has thus emerged as a ...
Aubin Ramon, Niccolò Frassetto, Haowen Zhao, Xing Xu, Matthew Greenig, Shimobi Onuoha, Pietro Sormanni   +6 more
doaj   +1 more source