Results 101 to 110 of about 1,117 (238)
, 2004 Surface developability is required in a variety of applications in product design, such as clothing, ship hulls, automobile parts, etc. However, most current geometric modeling systems using polygonal surfaces ignore this important intrinsic geometric ...
Wang, Charlie C.L. +2 more
core +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
A first insight into the developability of an Immunoglobulin G3 : a combined computational and experimental approach [PDF]
Immunoglobulin G 3 (IgG3) monoclonal antibodies (mAbs) are high-value scaffolds for developing novel therapies. Despite their wide-ranging therapeutic potential, IgG3 physicochemical properties and developability characteristics remain largely under ...
Taylor, Paul +7 more
core +1 more source
, 2020 Monoclonal antibodies (mAbs) for therapeutic applications should be as similar to native human antibodies as possible to minimize their immunogenicity in patients.
Philip A Leighton +28 more
core +1 more source
An antibody developability triaging pipeline exploiting protein language models
Therapeutic monoclonal antibodies (mAbs) are a successful class of biologic drugs that are frequently selected from phage display libraries and transgenic mice that produce fully human antibodies.
Andrew C.R. Martin, James Sweet-Jones
core +2 more sources
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
In vitro and in silico assessment of the developability of a designed monoclonal antibody library.
Despite major advances in antibody discovery technologies, the successful development of monoclonal antibodies (mAbs) into effective therapeutic and diagnostic agents can often be impeded by developability liabilities, such as poor expression, low ...
core +1 more source
The Importance and the Developability of Interpersonal Competency at Work: Implications for Higher Education [PDF]
, 2007 2007The purpose of this study was to derive behavior indicators of interpersonal competency based on competency model used by business organizations in Korea and to explore the importance and the developability of those indicators.
Kim, Changdai +3 more
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FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
Developability screening approaches for efficient protein discovery
University of Minnesota Ph.D. dissertation. October 2024. Major: Chemical Engineering. Advisor: Benjamin Hackel. 1 computer file (PDF); xii, 102 pages.Engineered protein therapeutics have greatly improved human health by providing novel treatments for ...
Nielsen, Gregory
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