Results 81 to 90 of about 14,908,548 (354)

Shape Optimization of Free-form Shells Considering Strain Energy and Algebraic Invariants of Parametric Surface

, 2009
p. 525-535A new approach is proposed for shape optimization of shell surfaces, where requirements on the aesthetic aspect and the constructability as well as the structural rationality are simultaneously considered in the problem formulation. The surface
FUJITA, Shinnosuke, OHSAKI, Makoto
core   +1 more source

The MedSupport Multilevel Intervention to Enhance Support for Pediatric Medication Adherence: Development and Feasibility Testing

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction We developed MedSupport, a multilevel medication adherence intervention designed to address root barriers to medication adherence. This study sought to explore the feasibility and acceptability of the MedSupport intervention strategies to support a future full‐scale randomized controlled trial.
Elizabeth G. Bouchard, Hital Patel, Paula C. Vincent, Justine Kahn, Kira Bona, Thai Hoa Tran, Elisa M. Rodriguez, Kristopher Attwood, Kara M. Kelly   +8 more
wiley   +1 more source

Macro- and Micro-Heterogeneity of Natural and Recombinant IgG Antibodies

Antibodies, 2019
Recombinant monoclonal antibodies (mAbs) intended for therapeutic usage are required to be thoroughly characterized, which has promoted an extensive effort towards the understanding of the structures and heterogeneity of this major class of molecules ...
Alain Beck, Hongcheng Liu
doaj   +1 more source

Antibody Conjugates-Recent Advances and Future Innovations

Antibodies, 2020
Monoclonal antibodies have evolved from research tools to powerful therapeutics in the past 30 years. Clinical success rates of antibodies have exceeded expectations, resulting in heavy investment in biologics discovery and development in addition to ...
Donmienne Leung, Jacqueline M. Wurst, Tao Liu, Ruben M. Martinez, Amita Datta-Mannan, Yiqing Feng   +5 more
doaj   +1 more source

Optimizing Antibody Affinity and Developability Using a Framework–CDR Shuffling Approach—Application to an Anti-SARS-CoV-2 Antibody

Viruses, 2022
The computational methods used for engineering antibodies for clinical development have undergone a transformation from three-dimensional structure-guided approaches to artificial-intelligence- and machine-learning-based approaches that leverage the ...
Ranjani Gopal, Emmett Fitzpatrick, Niharika Pentakota, Akila Jayaraman, Kannan Tharakaraman, I. Capila   +5 more
semanticscholar   +1 more source

Non-smooth developable geometry for interactively animating paper crumpling [PDF]

, 2015
International audienceWe present the first method to animate sheets of paper at interactive rates, while automatically generating a plausible set of sharp features when the sheet is crumpled.
Amar M. B., Bridson R., Burgoon R., Camille Schreck, Charlie C. L. Wang, Coffin D. W., Damien Rohmer, Grinspun E., Jean-Francis Bloch, Julius D., Mahadevan L., Makela P., Marie-Paule Cani, Rose K., Shuo Jin, Simnett T. J., Steenberg B., Stefanie Hahmann, Thorpe J.-L.   +18 more
core   +3 more sources

Stereotactic Body Radiation Therapy for Pediatric, Adolescent, and Young Adult Patients With Osteosarcoma: Local Control Outcomes With Dosimetric Analysis

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background/Objectives Osteosarcoma is a radioresistant tumor that may benefit from stereotactic body radiation therapy (SBRT) for locoregional control in metastatic/recurrent disease. We report institutional practice patterns, outcomes, toxicity, and failures in osteosarcoma patients treated with SBRT.
Jenna Kocsis, Shauna R. Campbell, Jonathan Jang, Eashwar Somasundaram, Chandana A. Reddy, Jacob G. Scott, Lilyana Angelov, Peter M. Anderson, Matteo Trucco, Zachary Burke, Lukas Nystrom, Nathan Mesko, Anthony Magnelli, Erin S. Murphy   +13 more
wiley   +1 more source

Predicting and Interpreting Protein Developability via Transfer of Convolutional Sequence Representation

bioRxiv, 2022
Engineered proteins have emerged as novel diagnostics, therapeutics, and catalysts. Often, poor protein developability – quantified by expression, solubility, and stability – hinders utility.
Alexander W Golinski, Zachary D Schmitz, Gregory H Nielsen, Bryce Johnson, Diya Saha, Sandhya Appiah, B. Hackel, Stefano Martiniani   +7 more
semanticscholar   +1 more source

Flow-Induced Draping

, 2013
Crumpled paper or drapery patterns are everyday examples of how elastic sheets can respond to external forcing. In this Letter, we study experimentally a novel sort of forcing.
Eloy, Christophe, Schouveiler, Lionel
core   +3 more sources

Lifestyle Behaviors and Cardiotoxic Treatment Risks in Adult Childhood Cancer Survivors

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Higher doses of anthracyclines and heart‐relevant radiotherapy increase cardiovascular disease (CVD) risk. This study assessed CVD and CVD risk factors among adult childhood cancer survivors (CCSs) across cardiotoxic treatment risk groups and examined associations between lifestyle behaviors and treatment risks.
Ruijie Li, Raquel Revuelta Iniesta, Alan R. Barker, Dimitris Vlachopoulos, Tomáš Sláma, Christina Schindera, Fabiën N. Belle   +6 more
wiley   +1 more source