Results 41 to 50 of about 1,740,435 (334)

Prolonged Corrected QT Interval as an Early Electrocardiographic Marker of Cyclophosphamide‐Induced Cardiotoxicity in Pediatric Hematology and Oncology Patients

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Cyclophosphamide (CY) is associated with potentially fatal cardiotoxicity, yet no electrocardiographic indices have been established for early detection of CY‐induced cardiomyopathy. This study aimed to determine whether corrected QT interval (QTc) prolongation can predict early onset of CY‐related cardiac dysfunction in pediatric ...
Junpei Kawamura, Kentaro Ueno, Takuro Nishikawa, Yoshihiro Takahashi, Koji Nakae, Yasuhiro Okamoto   +5 more
wiley   +1 more source

Better statistical reporting does not lead to statistical rigour: lessons from two decades of pseudoreplication in mouse-model studies of neurological disorders

Molecular Autism
Background Accurately determining the sample size (“N”) of a dataset is a key consideration for experimental design. Misidentification of sample size can lead to pseudoreplication, a process of artificially inflating the number of experimental replicates
Constantinos Eleftheriou, Sarah Giachetti, Raven Hickson, Laura Kamnioti-Dumont, Robert Templaar, Alina Aaltonen, Eleni Tsoukala, Nawon Kim, Lysandra Fryer-Petridis, Chloe Henley, Ceren Erdem, Emma Wilson, Beatriz Maio, Jingjing Ye, Jessica C. Pierce, Kath Mazur, Lucia Landa-Navarro, Nina G. Petrović, Sarah Bendova, Hanan Woods, Manuela Rizzi, Vanesa Salazar-Sanchez, Natasha Anstey, Antonios Asiminas, Shinjini Basu, Sam A. Booker, Anjanette Harris, Sam Heyes, Adam Jackson, Alex Crocker-Buque, Aoife C. McMahon, Sally M. Till, Lasani S. Wijetunge, David JA Wyllie, Catherine M. Abbott, Timothy O’Leary, Peter C. Kind   +36 more
doaj   +1 more source

Parental age effects on neonatal white matter development

NeuroImage: Clinical, 2020
Objective: Advanced paternal age is associated with poor offspring developmental outcome. Though an increase in paternal age-related germline mutations may affect offspring white matter development, outcome differences could also be due to psychosocial ...
Oliver Gale-Grant, Daan Christiaens, Lucilio Cordero-Grande, Andrew Chew, Shona Falconer, Antonios Makropoulos, Nicholas Harper, Anthony N Price, Jana Hutter, Emer Hughes, Suresh Victor, Serena J Counsell, Daniel Rueckert, Joseph V Hajnal, A David Edwards, Jonathan O'Muircheartaigh, Dafnis Batalle   +16 more
doaj   +1 more source

A Systematic Review of Evidence on the Clinical Effectiveness of Surveillance Imaging in Children With Medulloblastoma and Ependymoma

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Surveillance imaging aims to detect tumour relapse before symptoms develop, but it's unclear whether earlier detection of relapse leads to better outcomes in children and young people (CYP) with medulloblastoma and ependymoma. This systematic review aims to identify relevant literature to determine the efficacy of surveillance magnetic ...
Lucy Shepherd, Melissa Taylor, Helen Fulbright, Bob Phillips   +3 more
wiley   +1 more source

Exploring the multiple-hit hypothesis of preterm white matter damage using diffusion MRI

NeuroImage: Clinical, 2018
Background: Preterm infants are at high risk of diffuse white matter injury and adverse neurodevelopmental outcome. The multiple hit hypothesis suggests that the risk of white matter injury increases with cumulative exposure to multiple perinatal risk ...
Madeleine L. Barnett, Nora Tusor, Gareth Ball, Andrew Chew, Shona Falconer, Paul Aljabar, Jessica A. Kimpton, Nigel Kennea, Mary Rutherford, A. David Edwards, Serena J. Counsell   +10 more
doaj   +1 more source

Maturational networks of human fetal brain activity reveal emerging connectivity patterns prior to ex-utero exposure

Communications Biology, 2023
A key feature of the fetal period is the rapid emergence of organised patterns of spontaneous brain activity. However, characterising this process in utero using functional MRI is inherently challenging and requires analytical methods which can capture ...
Vyacheslav R. Karolis, Sean P. Fitzgibbon, Lucilio Cordero-Grande, Seyedeh-Rezvan Farahibozorg, Anthony N. Price, Emer J. Hughes, Ahmed E. Fetit, Vanessa Kyriakopoulou, Maximilian Pietsch, Mary A. Rutherford, Daniel Rueckert, Joseph V. Hajnal, A. David Edwards, Jonathan O’Muircheartaigh, Eugene P. Duff, Tomoki Arichi   +15 more
doaj   +1 more source

Imaging brain development: The adolescent brain

NeuroImage, 2012
The past 15 years have seen a rapid expansion in the number of studies using neuroimaging techniques to investigate maturational changes in the human brain. In this paper, I review MRI studies on structural changes in the developing brain, and fMRI studies on functional changes in the social brain during adolescence.
openaire   +2 more sources

Enhanced pre-frontal functional-structural networks to support postural control deficits after traumatic brain injury in a pediatric population [PDF]

, 2017
Traumatic brain injury (TBI) affects the structural connectivity, triggering the re-organization of structural-functional circuits in a manner that remains poorly understood.
Bonifazi, Paolo, Cortes, Jesus M, Diez, Ibai, Drijkoningen, David, Gooijers, Jolien, Marinazzo, Daniele, Stramaglia, Sebastiano, Swinnen, Stephan P   +7 more
core   +3 more sources

Prognostic Impact of Treatment Modalities, Including Targeted Compartmental Radio‐Immunotherapy, in a Cohort of Neuroblastoma Patients With CNS Metastases at Relapse

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction Neuroblastoma (NB) with central nervous system (CNS) metastases is rare at diagnosis, but occurs more often during relapse/progression. Patients with CNS metastases face a dismal prognosis, with no standardized curative treatment available.
Vicente Santa‐Maria Lopez, Anna Felip‐Badia, Marina Caballero‐Bellon, Nazaret Sanchez‐Sierra, Alicia Castañeda, Moira Garraus, Maite Gorostegui, Margarida Simão‐Rafael, Juan Pablo Muñoz, Marta Perez‐Somarriba, Salvador Mañe, Mariana Cecilia Planells, Sara Perez‐Jaume, Jaume Mora   +13 more
wiley   +1 more source

Recent advances in diffusion neuroimaging: applications in the developing preterm brain [version 1; referees: 2 approved]

F1000Research, 2018
Measures obtained from diffusion-weighted imaging provide objective indices of white matter development and injury in the developing preterm brain. To date, diffusion tensor imaging (DTI) has been used widely, highlighting differences in fractional ...
Diliana Pecheva, Christopher Kelly, Jessica Kimpton, Alexandra Bonthrone, Dafnis Batalle, Hui Zhang, Serena J. Counsell   +6 more
doaj   +1 more source