Results 91 to 100 of about 3,151,387 (317)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Climate Finance Strategies: Analysis of International Experiences [PDF]

Countries use climate finance strategies to assess fiscal needs and guide public and private finances to achieve mitigation goals and meet adaptation challenges.
Inter-American Development Bank
core   +1 more source

Glycemic index of some protein-free food products for individuals with non-dialysis-dependent chronic kidney disease

Nutrition & Metabolism
Background Chronic kidney disease (CKD) is a major public health issue and the third leading cause of death globally. In the conservative phase of CKD, a low-protein diet is recommended to slow disease progression, and protein-free products are commonly ...
Alessandro Leone, Francesca Menichetti, Franca Criscuoli, Giovanni Fiorillo, Stefano Ravasenghi, Maria Cristina Casiraghi, Simona Bertoli   +6 more
doaj   +1 more source

Culture, Heritage and Sustainable Development

Annales, Series Historia et Sociologia
This paper investigates how culture and cultural heritage contribute to achieving the Sustainable Development Goals (SDGs) by transforming democratic and social practices.
Marjan Horvat
doaj   +1 more source

Plasma Pharmacokinetics of Polyphenols in a Traditional Japanese Medicine, Jumihaidokuto, Which Suppresses Propionibacterium acnes-Induced Dermatitis in Rats

Molecules, 2015
Most orally administered polyphenols are metabolized, with very little absorbed as aglycones and/or unchanged forms. Metabolic and pharmacokinetic studies are therefore necessary to understand the pharmacological mechanisms of polyphenols. Jumihaidokuto (
Takashi Matsumoto, Yousuke Matsubara, Yasuharu Mizuhara, Kyoji Sekiguchi, Junichi Koseki, Kazuaki Tsuchiya, Hiroaki Nishimura, Junko Watanabe, Atsushi Kaneko, Kazuya Maemura, Tomohisa Hattori, Yoshio Kase   +11 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Relationship between bmi and glomerular filtration rate in a large cohort initiating a weight loss program: differential contributions of fat mass, fat-free mass, and abdominal fat compartments

Nutrition Journal
Background The relationship between BMI and chronic kidney disease is controversial, likely due to the inability of BMI to accurately define body composition and adipose tissue distribution.
Alessandro Leone, Francesca Menichetti, Laila Vignati, Federica Sileo, Ramona De Amicis, Andrea Foppiani, Simona Bertoli, Alberto Battezzati   +7 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

IEEM: Integrated Economic-Environmental Modeling Platform

, 2019
The Integrated Economic-Environmental Model (IEEM) fills an important gap in the economic development literature and practitioner’s toolbox. At the core of IEEM is a future-looking computable general equilibrium framework that enables the analysis of the
Inter-American Development Bank
core   +1 more source

Interoperability at the Border: Coordinated Border Management Best Practices & Case Studies [PDF]

, 2010
Interoperability among government agencies at national borders, also known as coordinated border management (CBM), is a fundamental component of a nation\u27s modernized customs and border control strategy.
Inter-American Development Bank
core   +1 more source