Results 111 to 120 of about 3,151,387 (317)

Increase in mechanical load and pro-fibrotic stimulation leads to fibrotic and hypertrophic remodeling in porcine living myocardial slices

Scientific Reports
Heart failure (HF) is a growing global health concern, driven by factors such as increased mechanical load of the heart muscle tissue. This pathogenic condition is the result of remodeling processes, partially mediated by the cytokine transforming growth
Marco Bentele, Sophie Linke, Susanne Neumüller, Andrea Korte, Anika Gietz, Annette Just, Angelika Stucki-Koch, Angelika Pfanne, Junqing Liu, Jiahao Zhao, Cornelia Schwennen, Christian Homann, Christian Visscher, Michael Pflaum, Bettina Wiegmann, Christian Bär, Natalie Weber, Jan Fiedler, Thomas Thum   +18 more
doaj   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Pakistan Rural Household Panel Survey (PRHPS) 2013, Round 2

, 2013
The Pakistan Rural Household Panel Survey (PRHPS) 2013, Round 2 is the second round of the PRHPS; Round 1 was conducted in 2012. This survey aims to provide a quantitative basis to identify and address urgent economic development and policy priorities in
Innovative Development Strategies (IDS), International Food Policy Research Institute (IFPRI)   +1 more
core   +1 more source

Short-term effects of Mediterranean diet on nutritional status in adults affected by Osteogenesis Imperfecta: a pilot study

Orphanet Journal of Rare Diseases
Background Osteogenesis Imperfecta (OI) is a heterogeneous group of connective tissue disorders, characterized by varying degrees of skeletal fragility.
Ramona De Amicis, Simona Bertoli, Amalia Bruno, Giulia De Carlo, Alberto Battezzati, Andrea Foppiani, Alessandro Leone, Antonella Lo Mauro   +7 more
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Biophysical approaches for studying viral entry

FEBS Letters, EarlyView.
Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley   +1 more source

Evaluation of the Bank\u27s Basic Education Strategy

, 2003
This report (RE-281) presents OVE\u27s evaluation of the Bank\u27s Basic Education Strategy. The document is organized as follows: Chapter I is an introduction, Chapter II presents an overview of the evolution of LAC\u27s basic education outcomes during ...
Inter-American Development Bank
core   +1 more source

Determinants of Glucose Tolerance in a Population Without Overt Diabetes: The Role of β-Cell Glucose Sensitivity, Insulin Sensitivity, and Insulin Clearance

Metabolites
Background/Objectives: To investigate how β-cell glucose sensitivity, insulin clearance, and insulin sensitivity interact to determine glucose tolerance in a population without overt diabetes.
Beatrice Marelli, Andrea Foppiani, Federica Sileo, Giorgia Pozzi, Silvia Gallosti, Chiara Cappellini, Andrea Mari, Simona Bertoli, Alberto Battezzati   +8 more
doaj   +1 more source