Results 121 to 130 of about 1,509,136 (297)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

Flame retarded polymer nanocomposites: Development, trend and future perspective

open access: yes, 2011
Polymer nanocomposites are a new class of flame retarded materials which have attracted much attention and considered as a revolutionary new flame retardant approach.
HaiYun Ma   +5 more
core   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

open access: yesMolecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel   +6 more
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

Key Technology and Development Trend of Permanent Magnet Motor Traction System for Rail Transit

open access: yes机车电传动, 2018
The characteristics and advantages of permanent magnet motor traction system in rail transit were introduced. The development status of permanent magnet motor traction system in rail transit at home and abroad was summarized.
FENG Jianghua
doaj  

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

open access: yesMolecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos   +6 more
wiley   +1 more source

Analysis on the geological structure and characteristic of Baige landslide in Jinshajiang tectonic melange belt

open access: yesShuiwen dizhi gongcheng dizhi
The Baige landslide is located in the Jinshajiang tectonic melange belt with extremely complex geological conditions. Understanding the geological structure features of the Baige area is of crucial importance for subsequent disaster risk assessment ...
Shilin ZHANG   +5 more
doaj   +1 more source

Economic Growth in Paraguay

open access: yes, 2004
This paper will examine the Paraguayan growth experience since the early 1960slooking at different periods to try to identify the main factors behind particular levels performance.
Inter-American Development Bank
core   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

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