Results 131 to 140 of about 1,509,136 (297)

The Development Trend of Medical Animals in the Last Ten Years: A Review. [PDF]

open access: yesIran J Public Health, 2023
Luo D   +5 more
europepmc   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

Development trend and typical applications of industrial big data

open access: yesDianxin kexue, 2016
The concept and characteristics of industrial big data were introduced,and its development trend was discussed.It meant that industrial big data cluld be widely used in the whole production process in manufacturing enterprises.According to application ...
Mingfeng HUANG
doaj  

Ferroptosis: A New Development Trend in Periodontitis. [PDF]

open access: yesCells, 2022
Chen K   +5 more
europepmc   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Wellhead Tieback Technology for Shallow Sea Well under Integrated Exploration-development Strategy

open access: yesShiyou jixie, 2018
According to relevant laws and regulations, at the end of well life, the exploratory well will either be permanently abandoned or temporary abandoned. The permanent abandonment requirement is stricter than the temporary abandonment.
Huo Hongbo   +6 more
doaj  

Biomimetic technologies for drill rods: Advances in research and development trends

open access: yesMeitian dizhi yu kantan
Significance Drill rods are recognized as core tools in drilling engineering, and their performance exerts a significant influence on drilling efficiency and safety.
Chuanliu WANG, Pei JU
doaj   +1 more source

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