Results 151 to 160 of about 37,171 (198)
Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids
FEBS Open Bio, EarlyView.Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão +3 more
wiley +1 more source
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA
FEBS Open Bio, EarlyView.PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro +1 more
wiley +1 more source
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Science, 1980
Polymer science and technology has flourished as polymers with many new compositions have been, synthesized. The range of properties attainable has been continually extended, providing materials with higher strength, better reinforcing capabilities, and greater resistance to extreme thermal and corrosive environments.
B C, Anderson +2 more
openaire +2 more sources
Polymer science and technology has flourished as polymers with many new compositions have been, synthesized. The range of properties attainable has been continually extended, providing materials with higher strength, better reinforcing capabilities, and greater resistance to extreme thermal and corrosive environments.
B C, Anderson +2 more
openaire +2 more sources
New trends in antimicrobial development
Current Medicinal Chemistry, 1998The continual evolution of microbial resistance to the available classes of antibiotics poses a serious threat to the efficacy of traditional antibacterial therapy. Today, there are two main approaches that are being applied to discover better and more effective anti-infective agents against common as well as resistant pathogens: (a) the improvement
E L, Setti, R G, Micetich
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Recent Developments and Trends
2009Although we often speak of ‘the’ environmental problem, what we in fact have is a large family of problems affecting the geophysical system, ecosystems and human health and varying enormously in magnitude, nature and temporal and spatial scale. There is a similar diversity in how these problems are framed conceptually by individual societies, under the
Reijnders, L. +2 more
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Developing Trends in Bioanalysis
Bioanalysis, 2009The Forum, initiated over 30 years ago by Eric Reid of the University of Surrey, after whom the Forum is now named, is held in Guildford at the University of Surrey every 2 years. This year's forum was the 18th in the series. There were over 30 oral presentations and more than 20 posters, together with suppliers' exhibitions on Tuesday and Wednesday ...
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Secular Trends in Pubertal Development
Hormone Research in Paediatrics, 2002<i>Objective:</i> To describe the secular trend in pubertal development in relation to the secular trend in height. <i>Methods:</i> Literature review of cross-sectional, longitudinal and twin studies. <i>Results:</i> Globally, there is a secular trend in adolescent growth for an increased mean final height at ...
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Trends in the Sensor Development
2015The current cyberspace also uses intensive development of sensors. The motivation are the requirements on control and informatics systems, security applications, monitoring and environmental protection, energy saving, health requirements etc. In the paper there are described the large-scale innovations of the sensor area for measuring the composition ...
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