Results 31 to 40 of about 181,587 (216)
Physiological inputs regulate species-specific anatomy during embryogenesis and regeneration
Communicative & Integrative Biology, 2016 A key problem in evolutionary developmental biology is identifying the sources of instructive information that determine species-specific anatomical pattern.
Kelly G. Sullivan +2 more
doaj +1 more source
F1000Research, 2017 In the rat testis, studies have shown that cell polarity, in particular spermatid polarity, to support spermatogenesis is conferred by the coordinated efforts of the Par-, Crumbs-, and Scribble-based polarity complexes in the seminiferous epithelium ...
Linxi Li +8 more
doaj +1 more source
Mad is required for wingless signaling in wing development and segment patterning in Drosophila.
PLoS ONE, 2009 A key question in developmental biology is how growth factor signals are integrated to generate pattern. In this study we investigated the integration of the Drosophila BMP and Wingless/GSK3 signaling pathways via phosphorylations of the transcription ...
Edward Eivers +5 more
doaj +1 more source
Chick fetal organ spheroids as a model to study development and disease
BMC Molecular and Cell Biology, 2021 Background Organ culture models have been used over the past few decades to study development and disease. The in vitro three-dimensional (3D) culture system of organoids is well known, however, these 3D systems are both costly and difficult to culture ...
Soran Dakhel +5 more
doaj +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Adolescents with high‐risk cancer face complex developmental, psychosocial, and ethical challenges that extend beyond disease‐directed treatment. Although international recommendations exist for communication, psychosocial care, pediatric palliative care, survivorship, and shared decision‐making, these have largely evolved within ...
Johanna M. C. Blom +15 more
wiley +1 more source
Scientific Reports, 2023 The Japanese rhinoceros beetle Trypoxylus dichotomus is a giant beetle with distinctive exaggerated horns present on the head and prothoracic regions of the male. T.
Shinichi Morita +21 more
doaj +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Children with sickle cell anemia (SCA) in low‐income settings are at risk of severe malnutrition, but optimal nutritional management has not been established. We evaluated an intensified ready‐to‐use therapeutic food (RUTF) regimen in children with persistent severe malnutrition after initial treatment and assessed whether early ...
Safiya Gambo +9 more
wiley +1 more source
Theoretical and experimental approaches to understand morphogen gradients
Molecular Systems Biology, 2008 Morphogen gradients, which specify different fates for cells in a direct concentration‐dependent manner, are a highly influential framework in which pattern formation processes in developmental biology can be characterized.
Marta Ibañes +1 more
doaj +1 more source
Probing three-dimensional collective cancer invasion with DIGME
Cancer Convergence, 2017 Background Multicellular pattern formation plays an important role in developmental biology, cancer metastasis and wound healing. While many physical factors have been shown to regulate these multicellular processes, the role of ECM micro-to-meso scale ...
Amani A. Alobaidi, Bo Sun
doaj +1 more source
Comparative Drug Response Profiling in Neuroblastoma Cell Lines and Patient‐Derived Tumor Organoids
Pediatric Blood &Cancer, EarlyView.ABSTRACT High‐risk neuroblastoma remains a leading cause of pediatric cancer mortality, and improved preclinical models are needed to guide therapeutic developments. We screened seven high‐risk neuroblastoma cell lines and three patient‐derived tumor organoids with 528 compounds alongside bone marrow controls, and compared them with external datasets ...
Krzysztof Wierbiłowicz +12 more
wiley +1 more source