Results 51 to 60 of about 201,067 (302)

Positional Information—A concept underpinning our understanding of developmental biology

Developmental Dynamics, 2020
It is now 50 years since Lewis Wolpert published the paper in which he set out the concept of Positional Information to explain how spatial patterns of cellular differentiation are generated.
N. Vargesson
semanticscholar   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Spatial pattern formation in chemical and biological systems

, 1997
One of the central issues in developmental biology is the formation of spatial pattern in the embryo. A number of theories have been proposed to account for this phenomenon.
Chau H. N. P., Maini, P K, Painter, Kevin, Painter K. J., Maini, P. K., Maini P. K., Painter, K. J., Chau, H. N. P., Maini, Philip, Nguyen, Helene Phong Chau, Maini, PK, Painter, KJ, Chau, HNP   +12 more
core   +1 more source

From genes to patterns: a framework for modeling the emergence of embryonic development from transcriptional regulation

Frontiers in Cell and Developmental Biology
Understanding embryonic patterning, the process by which groups of cells are partitioned into distinct identities defined by gene expression, is a central challenge in developmental biology.
Jimena Garcia-Guillen, Ezzat El-Sherif
doaj   +1 more source

Pattern formation mechanisms of self-organizing reaction-diffusion systems

Developmental Biology, 2019
Embryonic development is a largely self-organizing process, in which the adult body plan arises from a ball of cells with initially nearly equal potency.
Amit N. Landge, B. M. Jordan, Xavier Diego, Patrick Müller   +3 more
semanticscholar   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

An envelope method for analysing sequential pattern formation

, 2000
We examine sequential spatial pattern formation in a tissue interaction model for skin organ morphogenesis. Pattern formation occurs as a front sweeps across the domain leaving in its wake a steady state spatial pattern.
Cruywagen, GC, Maini, P. K., Murray, JD, Murray, J. D., Maini, Philip, Maini, PK, Cruywagen, G. C.   +6 more
core   +1 more source

TGF-β signaling molecules in Hydra: role of BMP and BMP inhibitors during pattern formation.

International Journal of Developmental Biology
Understanding the evolution of body plans has been one of the major areas of investigation in developmental and evolutionary biology. Cnidaria, the sister group to bilaterians, provides an opportunity to elucidate the origin and evolution of body axes ...
L. Krishnapati, S. Ghaskadbi
semanticscholar   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source