Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
FEBS Letters, EarlyView.Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
The paradise fish, an advanced animal model for behavioral genetics and evolutionary developmental biology [PDF]
, 2023 Nóra Szabó +6 more
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Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
Schekman, R., Goldstein, L., McKnight, S.L., Rossant, J. (ed.): Annual Review of Cell and Developmental Biology. Vol. 16 [PDF]
, 2001 T. Gichner
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Dysfunctions of highly parallel real-time machines as 'developmental disorders': Security concerns and a Caveat Emptor [PDF]
, 2009 A cognitive paradigm for gene expression in developmental biology that is based on rigorous application of the asymptotic limit theorems of information theory can be adapted to highly parallel real-time computing.
Wallace, Rodrick
core
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Synthetic developmental biology: Engineering approaches to guide multicellular organization [PDF]
, 2022 Ibrahim Zarkesh +5 more
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Multidisciplinary teaching of Biotechnology and Omics sciences [PDF]
, 2017 In the last years, there was a great boom in the Omics fields that have developed as multidisciplinary sciences. They use laboratory techniques related to Biology and Chemistry but also Bioinformatics tools. However, the developmental progress of these
Canovas-Ramos, Francisco Miguel +6 more
core
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
Reproductive and developmental biology of rice field crab Esanthelphusa nani (Naiyanetr, 1984) [PDF]
, 2019 Rachata Maneein
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