Results 81 to 90 of about 580,764 (305)

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Elimination of cells with local mismatch in differentiation timing contributes to synchronize tissue development

iScience
Summary: During animal development, cells communicate to ensure tissue-wide synchronization of differentiation. While several mechanisms contributing to cell coordination have been described, whether additional mechanisms are at play should cells locally
Maleaume Soulard, Diego Andrés Contreras, Bruno Monier, Thomas Mangeat, Vanessa Dougados, Jennifer Zanet, Francis Corson, Vincent Hakim, François Payre, Anne Pélissier-Monier   +9 more
doaj   +1 more source

Polarity control of spindle positioning in the C. elegans embryo

, 2015
Cell and tissue polarity guide a large variety of developmental processes, in-cluding the choice between symmetric and asymmetric cell division. Asymmetric divisions create cell diversity and are needed for maintenance of tissue specific stem cells ...
Sub Developmental Biology, van den Heuvel, Sander, Lars-Eric Fielmich, Fielmich, Lars-Eric, Developmental Biology, Sander van den Heuvel, Ebnet, Klaus   +6 more
core   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Developmental Biology — Expanding the Horizon

Journal of Developmental Biology, 2012
Developmental biology is arguably the most exciting field of study within the biological sciences. To elucidate how complex organisms develop from a single cell into a complex organism is a quest that has captured the minds of many great scientists. [...]
Andy Wessels
doaj   +1 more source

The nature and dynamics of spermatogonial stem cells [PDF]

, 2017
Spermatogonial stem cells (SSCs) are crucial for maintaining spermatogenesis throughout life, and understanding how these cells function has important implications for understanding male infertility. Recently, various populations of cells harbouring stem
de Rooij, Dirk G., Sub Developmental Biology, Developmental Biology, Dirk G. de Rooij   +3 more
core   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

RAD21 deficiency drives corneal to scleral differentiation fate switching via upregulating WNT9B

iScience
Summary: The cornea and sclera are distinct adjacent tissues, yet their stromal cells originate from common neural crest cells (NCCs). Sclerocornea is a disease characterized by an indistinguishable boundary between the cornea and sclera.
Hongyan Liu, Benxiang Qi, Guanghui Liu, Haoyun Duan, Zongyi Li, Zhaoying Shi, Yonglong Chen, Wai Kit Chu, Qingjun Zhou, Bi Ning Zhang   +9 more
doaj   +1 more source

Determination of the cell cleavage plane by the LIN-5 complex

, 2011
Cells split in two at the final step of each division cycle. This division normally bisects through the middle of the cell and generates two equal daughters.
Galli, M., Sub Developmental Biology, Developmental Biology   +2 more
core