Results 71 to 80 of about 1,157,389 (344)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Developmental changes of the mitochondria in the murine anteroventral cochlear nucleus

iScience
Summary: Mitochondria are key organelles to provide ATP for synaptic transmission. This study aims to unravel the structural adaptation of mitochondria to an increase in presynaptic energy demand and upon the functional impairment of the auditory system.
Anika Hintze, Felix Lange, Anna M. Steyer, Jannis Anstatt, Wiebke Möbius, Stefan Jakobs, Carolin Wichmann   +6 more
doaj   +1 more source

Developmental Biology — Expanding the Horizon

Journal of Developmental Biology, 2012
Developmental biology is arguably the most exciting field of study within the biological sciences. To elucidate how complex organisms develop from a single cell into a complex organism is a quest that has captured the minds of many great scientists. [...]
Andy Wessels
doaj   +1 more source

Reproductive tract biology: Of mice and men. [PDF]

, 2019
The study of male and female reproductive tract development requires expertise in two separate disciplines, developmental biology and endocrinology.
Baskin, Laurence S, Cao, Mei, Cunha, Gerald R, Ricke, Will A, Robboy, Stanley J, Sinclair, Adriane   +5 more
core  

Isolating and Quantifying the Role of Developmental Noise in Generating Phenotypic Variation [PDF]

, 2018
Genotypic variation, environmental variation, and their interaction may produce variation in the developmental process and cause phenotypic differences among individuals. Developmental noise, which arises during development from stochasticity in cellular
Chiari, Ylenia, Gamble, Tony, Glimm, Tilmann, Kiskowski, Maria, Moreno, Nickolas   +4 more
core   +5 more sources

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Robust and Irreversible Development in Cell Society as a General Consequence of Intra-Inter Dynamics

, 1999
A dynamical systems scenario for developmental cell biology is proposed, based on numerical studies of a system with interacting units with internal dynamics and reproduction.
Eigen, Furusawa, Furusawa, Goodwin, Gourdon, Greenwald, Hess, Kaneko, Kaneko, Kaneko, Kaneko, Kaneko, Kaneko, Kaneko, Kaneko, Kaneko, Kaneko, Kaneko, Kaneko (Ed.), Kauffman, Newman, Ogawa, Turing   +22 more
core   +2 more sources

Toward high-content/high-throughput imaging and analysis of embryonic morphogenesis [PDF]

, 2011
In vivo study of embryonic morphogenesis tremendously benefits from recent advances in live microscopy and computational analyses. Quantitative and automated investigation of morphogenetic processes opens the field to high-content and high-throughput ...
Supatto, Willy, Truong, Thai V.
core   +4 more sources

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Different populations of mouse egg cortical vesicles are responsible for post-fertilization zinc sparks and proteolysis of the zona pellucida

iScience
Summary: Fertilization of mouse eggs by sperm triggers exocytosis of cortical granules, releasing zinc sparks as well as ovastacin that cleaves ZP2 in the zona pellucida. The mechanism by which zinc accumulates in cortical granules prior to fertilization
Omar José, Boris Baibakov, Jurrien Dean
doaj   +1 more source