Results 21 to 30 of about 76,010 (254)

Prenatal to early postnatal neurotrophic treatment prevents Alzheimer-like behavior and pathology in mice

Alzheimer’s Research & Therapy, 2020
Background Alzheimer’s disease (AD) is a progressive neurodegenerative disorder of middle-aged to old individuals. The pathophysiological process of AD is believed to begin many years before the emergence of clinical symptoms.
Wei Wei, Yifan Wang, Yinghua Liu, Chun-Ling Dai, Yunn-Chyn Tung, Fei Liu, Khalid Iqbal   +6 more
doaj   +1 more source

Young blood plasma reduces Alzheimer’s disease-like brain pathologies and ameliorates cognitive impairment in 3×Tg-AD mice

Alzheimer’s Research & Therapy, 2020
Background Recent studies indicated that circulatory factors in blood plasma from young animals can reactivate neurogenesis, restore synaptic plasticity, and improve cognitive function in aged animals.
Ying Zhao, Ran Qian, Jin Zhang, Fei Liu, Khalid Iqbal, Chun-Ling Dai, Cheng-Xin Gong   +6 more
doaj   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Sensory seeking and its influence on sustained attention performance in adult males with Autism Spectrum Condition

Scientific Reports
Atypical sensory responses and seeking behaviors constitute the core symptoms of autism spectrum condition (ASC). There are possible links between atypical sensory profiles and attentional challenges in ASC.
Takashi Itahashi, Ryuta Aoki, Motoaki Nakamura, Haruhisa Ohta, Ryu-ichiro Hashimoto   +4 more
doaj   +1 more source

The Recommendations for the Management of Chinese Children With Epilepsy During the COVID-19 Outbreak

Frontiers in Pediatrics, 2020
The coronavirus disease (COVID-19) is the most severe public health problem facing the world currently. Social distancing and avoidance of unnecessary movements are preventive strategies that are being advocated to prevent the spread of the causative ...
Baiyu Chen, Baiyu Chen, Miriam Kessi, Miriam Kessi, Shimeng Chen, Shimeng Chen, Juan Xiong, Juan Xiong, Liwen Wu, Liwen Wu, Xiaolu Deng, Xiaolu Deng, Lifen Yang, Lifen Yang, Fang He, Fang He, Fei Yin, Fei Yin, Jing Peng, Jing Peng   +19 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Correction: Samadi et al. Autism Spectrum Disorder Diagnostic Criteria Changes and Impacts on the Diagnostic Scales-Utility of the 2nd and 3rd Versions of the Gilliam Autism Rating Scale (GARS). Brain Sci. 2022, 12, 537

Brain Sciences, 2023
In the original publication [...]
Sayyed Ali Samadi, Cemal A. Biçak, Hana Noori, Barez Abdalla, Amir Abdullah, Lizan Ahmed   +5 more
doaj   +1 more source

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

FEBS Open Bio, EarlyView.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source

Age‐related retinal thickness in Down's syndrome: A high‐risk population for dementia

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 2019
Introduction People with Down's syndrome (DS) have a high prevalence of early‐onset Alzheimer's disease. Early markers of Alzheimer's disease pathology identifiable before clinical change are needed for the evaluation of preventative treatments.
Madeleine J. Walpert, Eduardo M. Normando, Tiina Annus, Sally R. Jennings, Liam R. Wilson, Peter Watson, Shahid H. Zaman, M. Francesca Cordeiro, Anthony J. Holland   +8 more
doaj   +1 more source