Results 41 to 50 of about 1,165,493 (278)

Validation of the safety, empathy and utility of a large language model conversation agent for parents of autistic and neurodivergent children

Scientific Reports
This paper presents three descriptive validation studies of a large language model (LLM) conversation agent designed to support families and carers with autistic children.
Freddy Jackson Brown, Isabelle Stewart Muscat, Louise Quinn, Lara Best, Paul Cooper   +4 more
doaj   +1 more source

Dactolisib outperforms Rapamycin in potentiating apoptosis induced by XPO1, Bcl‐2 and Mcl‐1 blockade in preclinical glioblastoma models

FEBS Open Bio, EarlyView.
The PAM pathway and its impact on cellular metabolism. Color‐coded key symbols represent Rapamycin (R, orange, targeting mTOR) and Dactolisib (D, green, targeting PI3K/mTOR), indicating their sites of action. Created with BioRenders.com. Glioblastoma resists therapy through interconnected survival programs.
Kai Zhao, Leonie Meyer, Madita Braun, Katharina Otte, Celine Bitter, Maite Pawlik, Hartmann Raifer, Frederik Helmprobst, Axel Pagenstecher, Hans Urban, Michael C. Burger, Michael W. Ronellenfitsch, Joachim P. Steinbach, Jarmila Jedelská, Shamim Bagheri, Behrooz H. Yousefi, Pietro Di Fazio, Markus Luster, Andreas H. Mahnken, Andreas Neubauer, Andreas Burchert, Christopher Nimsky, Jörg W. Bartsch, Tillmann Rusch   +23 more
wiley   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Ethical Foreground and Background in Adult Educator Work

New Directions for Adult and Continuing Education, EarlyView.
ABSTRACT Adult educators work in a complex ethical environment. The very act of contributing to the learning of another is fraught with moral overtones. In this paper we consider the ethical dimensions of adult educator practice by distinguishing the ethical features of the context or ‘background’ of practice from the ethical capabilities and decision ...
Steven Hodge, Sonal Nakar
wiley   +1 more source

Barriers to Health Care Among Adults with Disabilities in Connecticut

Developmental Disabilities Network Journal
It is estimated that 25% of adults in the US are living with one or more disabilities. Persons with disabilities (PWD) have unmet health care needs, experience health disparities compared to those without disabilities.
Mary Beth Bruder, PhD, Tara M. Lutz, PhD, Kelly E. Ferreira, PhD   +2 more
doaj   +1 more source

Microarray Analysis Reveals Higher Gestational Folic Acid Alters Expression of Genes in the Cerebellum of Mice Offspring—A Pilot Study

Brain Sciences, 2015
Folate is a water-soluble vitamin that is critical for nucleotide synthesis and can modulate methylation of DNA by altering one-carbon metabolism. Previous studies have shown that folate status during pregnancy is associated with various congenital ...
Subit Barua, Salomon Kuizon, Kathryn K. Chadman, W. Ted Brown, Mohammed A. Junaid   +4 more
doaj   +1 more source

Tau seeding activity in various regions of down syndrome brain assessed by two novel assays

Acta Neuropathologica Communications, 2022
Propagation of tau pathology via the seeding of naive tau aggregation underlies the progression of Alzheimer’s disease (AD) and related tauopathies. Individuals with Down syndrome (DS) develop tau pathology at the fourth decade of life, but tau seeding ...
Nana Jin, Jianlan Gu, Ruozhen Wu, Dandan Chu, Yunn Chyn Tung, Jerzy Wegiel, Thomas Wisniewski, Cheng-Xin Gong, Khalid Iqbal, Fei Liu   +9 more
doaj   +1 more source

Understanding Further the Phenotypic Spectrum of Central Nervous System Inflammatory Demyelinating Disorders Using Unsupervised Clustering

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Central nervous system (CNS) inflammatory demyelinating syndromes, including multiple sclerosis (MS), aquaporin‐4 antibody–positive neuromyelitis optica spectrum disorder (AQP4 + NMOSD), and myelin oligodendrocyte glycoprotein (MOG) antibody–associated disease (MOGAD), occasionally overlap.
Bade Gulec, Elif Everest, Melih Tutuncu, Ugur Bilge, Sabahattin Saip, Ugur Uygunoglu, Aksel Siva   +6 more
wiley   +1 more source

Other title: Title from HTML header (viewed May 20, 2011): CTCDD-Ct. Council on Developmental Disabilities; Other title: Connecticut Council on Developmental Disabilities

, 2012
Updated irregularly; Began in 2002?; Title from home page (publisher's Web site, viewed May 20, 2011).; At head of title: Connecticut.; Harvested from the web on 12/12/12Official website of the Connecticut Developmental Disabilities Council.

core   +1 more source

Self-Determination Research: Current and Future Directions

Behavioral Sciences
This article summarizes the history, current status, and future directions of self-determination research across the globe, with a focus on applications to the education of students with intellectual and developmental disabilities and their transition ...
Kathryn M. Burke, Karrie A. Shogren, Andrea Parente, Abdulaziz Alsaeed, Austin M. Myers, Shawn Aleong   +5 more
doaj   +1 more source