Results 41 to 50 of about 78,321 (263)

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Advancing Diversity, Equity, and Inclusion in Developmental Disabilities: The Essential Role of Leadership for Cultural and Linguistic Competence

Developmental Disabilities Network Journal, 2023
There is a clear and compelling need to approach equity, diversity, and inclusion not as problems to be solved,but rather as opportunities to be realized.
Tawara D. Goode, Oluwatosin Ajisope, Sharonlyn Harrison, Betelhem Eshetu Yimer, Deborah Perry, Wendy Jones   +5 more
doaj   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Age‐related retinal thickness in Down's syndrome: A high‐risk population for dementia

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 2019
Introduction People with Down's syndrome (DS) have a high prevalence of early‐onset Alzheimer's disease. Early markers of Alzheimer's disease pathology identifiable before clinical change are needed for the evaluation of preventative treatments.
Madeleine J. Walpert, Eduardo M. Normando, Tiina Annus, Sally R. Jennings, Liam R. Wilson, Peter Watson, Shahid H. Zaman, M. Francesca Cordeiro, Anthony J. Holland   +8 more
doaj   +1 more source

Neurological Diseases With Autism Spectrum Disorder: Role of ASD Risk Genes

Frontiers in Neuroscience, 2019
Autism spectrum disorder (ASD) is frequently comorbid with other neurological disorders such as intellectual disability (ID) or global development delay (GDD) and epilepsy. The pathogenesis of ASD is complex.
Juan Xiong, Juan Xiong, Shimeng Chen, Shimeng Chen, Nan Pang, Nan Pang, Xiaolu Deng, Xiaolu Deng, Lifen Yang, Lifen Yang, Fang He, Fang He, Liwen Wu, Liwen Wu, Chen Chen, Chen Chen, Fei Yin, Fei Yin, Jing Peng, Jing Peng   +19 more
doaj   +1 more source

Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer

Aging and Cancer, EarlyView.
Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss, Alexis C. Wardell, Allison M. Deal, Kirsten A. Nyrop, Allison Ross, Yara G. Abdou, Jeffrey D. Aldrich, Lisa A. Cary, E. Claire Dees, Katherine E. Reeder‐Hayes, Emily M. Ray, Natalia Mitin, Denis Tsygankov   +12 more
wiley   +1 more source

Validation of the safety, empathy and utility of a large language model conversation agent for parents of autistic and neurodivergent children

Scientific Reports
This paper presents three descriptive validation studies of a large language model (LLM) conversation agent designed to support families and carers with autistic children.
Freddy Jackson Brown, Isabelle Stewart Muscat, Louise Quinn, Lara Best, Paul Cooper   +4 more
doaj   +1 more source

Artificial Intelligence and Mental Well‐Being in Adult Education: Implications for Practice and Professional Responsibility

New Directions for Adult and Continuing Education, EarlyView.
ABSTRACT Mental well‐being is central to adult learner success, yet many adult education institutions lack capacity to provide timely and accessible support. This article examines how artificial intelligence (AI) can strengthen mental health–adjacent supports in adult and continuing higher education, with attention to professional practice and ...
Adam L. McClain, Thomas Wade
wiley   +1 more source

Treatment for the Benign Childhood Epilepsy With Centrotemporal Spikes: A Monocentric Study

Frontiers in Neurology, 2021
Background and Purpose: To date, there is no specific treatment guideline for the benign childhood epilepsy with centrotemporal spikes (BECTS). Several countries recommend levetiracetam, carbamazepine, sodium valproate, oxcarbazepine, and lamotrigine as ...
Miriam Kessi, Miriam Kessi, Fangling Yan, Fangling Yan, Langui Pan, Langui Pan, Baiyu Chen, Baiyu Chen, Eleonore Olatoutou, Eleonore Olatoutou, Dong Li, Dong Li, Fang He, Fang He, Tibera Rugambwa, Lifen Yang, Lifen Yang, Jing Peng, Jing Peng, Fei Yin, Fei Yin   +20 more
doaj   +1 more source