Results 21 to 30 of about 78,321 (263)

Chronic Cerebral Hypoperfusion Causes Decrease of O-GlcNAcylation, Hyperphosphorylation of Tau and Behavioral Deficits in Mice

Frontiers in Aging Neuroscience, 2014
Chronic cerebral hypoperfusion (CCH) is one of the causes of vascular dementia (VaD) and is also an etiological factor for Alzheimer's disease (AD).
Yang eZhao, Yang eZhao, Jin-hua eGu, Jin-hua eGu, Chun-ling eDai, Qun eLiu, Khalid eIqbal, Fei eLiu, CHENG-XIN eGONG   +8 more
doaj   +1 more source

Hyperphosphorylation-induced tau oligomers

Frontiers in Neurology, 2013
In normal adult brain the microtubule associated protein tau contains 2–3 phosphates per mole of the protein and at this level of phosphorylation it is a soluble cytosolic protein.
Khalid eIqbal, CHENG-XIN eGONG, Fei eLiu
doaj   +1 more source

Deficit of corpus callosum axons, reduced axon diameter and decreased area are markers of abnormal development of interhemispheric connections in autistic subjects

Acta Neuropathologica Communications, 2018
Introduction In autism spectrum disorder, lack of coherence and of complex information processing, and narrowly focused interests and repetitive behaviors are considered a sign of long-range underconnectivity and short-range overconnectivity. The goal of
Jarek Wegiel, Wojciech Kaczmarski, Michael Flory, Veronica Martinez-Cerdeno, Thomas Wisniewski, Krzysztof Nowicki, Izabela Kuchna, Jerzy Wegiel   +7 more
doaj   +1 more source

DNA methylation profiling at single-base resolution reveals gestational folic acid supplementation influences the epigenome of mouse offspring cerebellum

Frontiers in Neuroscience, 2016
It is becoming increasingly more evident that lifestyle, environmental factors, and maternal nutrition during gestation can influence the epigenome of the developing fetus and thus modulate the physiological outcome. Variations in the intake of maternal
Subit eBarua, Subit eBarua, Salomon eKuizon, W. Ted eBrown, Mohammed A. Junaid   +4 more
doaj   +1 more source

Intranasal insulin prevents anesthesia-induced hyperphosphorylation of tau in 3xTg-AD mice

Frontiers in Aging Neuroscience, 2014
Background: It is well documented that elderly individuals are at increased risk of cognitive decline after anesthesia. General anesthesia is believed to be a risk factor for Alzheimer’s disease (AD).
Yanxing eChen, Xiaoqin eRun, Zhihou eLiang, Yang eZhao, CHUN-LING eDAI, Khalid eIqbal, Fei eLiu, CHENG-XIN eGONG   +7 more
doaj   +1 more source

Prediction of life satisfaction from resting‐state functional connectome

Brain and Behavior, 2021
Background Better life satisfaction (LS) is associated with better psychological and psychiatric outcomes. To the best of our knowledge, no studies have examined prediction models for LS. Methods Using resting‐state functional magnetic resonance imaging (
Takashi Itahashi, Neda Kosibaty, Ryu‐Ichiro Hashimoto, Yuta Y. Aoki   +3 more
doaj   +1 more source

Urine Organic Acids as Metabolic Indicators for Global Developmental Delay/Intellectual Disability in Chinese Children

Frontiers in Molecular Biosciences, 2021
Objective: The purpose of this study was to search for differential metabolites in urine organic acids, and to characterize metabolic features that can be used to identify metabolites for exploration of global developmental delay (GDD)/intellectual ...
Baiyu Chen, Baiyu Chen, Yalan Zhan, Yalan Zhan, Miriam Kessi, Miriam Kessi, Shimeng Chen, Shimeng Chen, Juan Xiong, Juan Xiong, Xiaolu Deng, Xiaolu Deng, Lifen Yang, Lifen Yang, Jing Peng, Jing Peng, Fei Yin, Fei Yin, Fang He, Fang He   +19 more
doaj   +1 more source

Assessment of demographic and perinatal predictors of non-response and impact of non-response on measures of association in a population-based case control study: findings from the Georgia Study to Explore Early Development

Emerging Themes in Epidemiology, 2018
Background Participation in epidemiologic studies has declined, raising concerns about selection bias. While estimates derived from epidemiologic studies have been shown to be robust under a wide range of scenarios, additional empiric study is needed ...
Laura A. Schieve, Shericka Harris, Matthew J. Maenner, Aimee Alexander, Nicole F. Dowling   +4 more
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Rare Copy Number Variations and Predictors in Children With Intellectual Disability and Epilepsy

Frontiers in Neurology, 2018
Introduction: The concurrence of intellectual disability/global developmental delay and epilepsy (ID/GDD-EP) is very common in the pediatric population. The etiologies for both conditions are complex and largely unknown.
Miriam Kessi, Miriam Kessi, Juan Xiong, Juan Xiong, Liwen Wu, Liwen Wu, Lifen Yang, Lifen Yang, Fang He, Fang He, Chen Chen, Chen Chen, Nan Pang, Nan Pang, Haolin Duan, Haolin Duan, Wen Zhang, Wen Zhang, Ahmed Arafat, Ahmed Arafat, Fei Yin, Fei Yin, Jing Peng, Jing Peng   +23 more
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Prenatal to early postnatal neurotrophic treatment prevents Alzheimer-like behavior and pathology in mice

Alzheimer’s Research & Therapy, 2020
Background Alzheimer’s disease (AD) is a progressive neurodegenerative disorder of middle-aged to old individuals. The pathophysiological process of AD is believed to begin many years before the emergence of clinical symptoms.
Wei Wei, Yifan Wang, Yinghua Liu, Chun-Ling Dai, Yunn-Chyn Tung, Fei Liu, Khalid Iqbal   +6 more
doaj   +1 more source