Results 91 to 100 of about 1,176,068 (282)

CNTF and Nrf2 Are Coordinately Involved in Regulating Self-Renewal and Differentiation of Neural Stem Cell during Embryonic Development

iScience, 2019
Summary: There is high risk of fetal neurodevelopmental defects in pregestational diabetes mellitus (PGDM). However, the effective mechanism of hyperglycemia-induced neurodevelopmental negative effects, including neural stem cell self-renewal and ...
Zhen-Peng Si, Guang Wang, Sha-Sha Han, Ya Jin, Yu-Xuan Hu, Mei-Yao He, Beate Brand-Saberi, Xuesong Yang, Guo-Sheng Liu   +8 more
doaj   +1 more source

Session 5: Development, Neuroscience and Evolutionary Psychology [PDF]

, 2002
Proceedings of the Pittsburgh Workshop in History and Philosophy of Biology, Center for Philosophy of Science, University of Pittsburgh, March 23-24 2001 Session 5: Development, Neuroscience and Evolutionary ...
Quartz, Steven, Machamer, Peter, Scarantino, Andrea, Sullivan, Jackie   +3 more
core  

Dimethyl Fumarate, But Not Rituximab, Reduces Serum GFAP Levels and PIRMA in Relapsing–Remitting MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Serum neurofilament light chain (sNfL) and glial fibrillary acidic protein (sGFAP) levels are believed to reflect mainly acute and chronic disease processes in multiple sclerosis (MS), respectively. In this study, we investigated whether dimethyl fumarate (DMF) and rituximab (RTX) differentially affect these biomarkers.
F. Shawket, J. Lycke, J. Salzer, F. Piehl, K. Fink, N. Lange, J. Mellergård, C. Malmeström, P. Sundström, I. Erngren, A. al‐Grety, E. Freyhult, K. Kultima, J. Burman, A. Svenningsson   +14 more
wiley   +1 more source

CircRNA Cdyl promotes the proliferation and differentiation of neural stem cells via regulating miR-544-3p/Nr3c1 axis

iScience
Summary: Emerging evidence suggests that numerous circular RNAs (circRNAs) are abnormally expressed during neural stem cell (NSC) differentiation, which may play an important role in the fate of NSCs.
Wen Li, Yujian Lin, Jingwen Wang, Zuotian Zhang, Jingjing Zhang, Yuzheng Zhang, Yuxuan Ge, Tiankun Yao, Xiang Cheng, Weiwei Chen, Min Xu, Xinhua Zhang   +11 more
doaj   +1 more source

Safety and Tolerability of Givinostat: Evidence From Real‐World and Clinical Practice

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The aim of our study was to establish the prevalence of adverse events in a real‐world setting in boys living with Duchenne muscular dystrophy (DMD) treated with givinostat as part of an Expanded Access Program (EAP) in Italy. Methods The cohort included 90 ambulant boys, with age when treatment started between 6 and 23 years (mean ...
Marika Pane, Anna Capasso, Chiara Arpaia, Adele D’Amico, Emilio Albamonte, Federica Trucco, Maria Sframeli, Riccardo Masson, Francesca Magri, Luca Bello, Romina Venditti, Claudia Dosi, Michela Catteruccia, Michele Tosi, Claudio Bruno, Sonia Messina, Giacomo Comi, Elena Pegoraro, Valeria A. Sansone, Eugenio Mercuri   +19 more
wiley   +1 more source

Inter-brain processes during Live and Represented social moments are inter-related and shaped by behavioral synchrony

Communications Psychology
Inter-brain synchrony has recently emerged as core mechanism of brain functioning. Two approaches distinctly measure cross-brain processes; during live social exchanges or passive observation of social stimuli, but are the two underpinned by similar ...
Linoy Schwartz, Carmel Shilo, Olga Hayut, Jaden Brandet, Jonathan Levy, Itai Peleg, Ruth Feldman   +6 more
doaj   +1 more source

Chromatin Remodeling BAF155 Subunit Regulates the Genesis of Basal Progenitors in Developing Cortex

iScience, 2018
Summary: The abundance of basal progenitors (BPs), basal radial glia progenitors (bRGs) and basal intermediate progenitors (bIPs), in primate brain has been correlated to the high degree of cortical folding. Here we examined the role of BAF155, a subunit
Ramanathan Narayanan, Linh Pham, Cemil Kerimoglu, Takashi Watanabe, Ricardo Castro Hernandez, Godwin Sokpor, Pauline Antonie Ulmke, Kamila A. Kiszka, Anton B. Tonchev, Joachim Rosenbusch, Rho H. Seong, Ulrike Teichmann, Jens Frahm, Andre Fischer, Stefan Bonn, Anastassia Stoykova, Jochen F. Staiger, Tran Tuoc   +17 more
doaj   +1 more source

Early Clinical, Imaging, and Pathological Characteristics of SRPK3/TTN‐Digenic Myopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective SRPK3/TTN‐digenic myopathy was recently established as a skeletal muscle myopathy caused by digenic inheritance. This study characterizes the early clinical presentation of SRPK3/TTN‐digenic myopathy in one previously reported and seven newly identified pediatric patients.
Rotem Orbach, Sandra Donkervoort, Carola Hedberg‐Oldfors, Giovanni Baranello, Dimah Saade, Precilla D'Souza, Ruchee Patel, Eva Michael, A. Reghan Foley, Diana Bharucha‐Goebel, S. Jin Haugland, Meghan McAnally, Omer Abdul Hamid, Katherine Chao, Ellen F. Macnamara, Alan H. Beggs, Anna Sarkozy, Juliane Mueller, Steven A. Moore, Richard S. Finkel, Cynthia J. Tifft, Francesco Muntoni, Anders Oldfors, Carsten G. Bönnemann   +23 more
wiley   +1 more source

The emergence of the multisensory brain: From the womb to the first steps

iScience
Summary: The becoming of the human being is a multisensory process that starts in the womb. By integrating spontaneous neuronal activity with inputs from the external world, the developing brain learns to make sense of itself through multiple sensory ...
Elena Nava, Michelle Giraud, Nadia Bolognini   +2 more
doaj   +1 more source

Caveolin-1 Promotes Early Neuronal Maturation via Caveolae-Independent Trafficking of N-Cadherin and L1

iScience, 2018
Summary: Axon specification is morphologically reproducible in vitro, whereas dendrite formation differs in vitro and in vivo. Cortical neurons initially develop immature neurites, but in vivo these are eliminated concurrently with the formation of a ...
Mima Shikanai, Yoshiaki V. Nishimura, Miwa Sakurai, Yo-ichi Nabeshima, Michisuke Yuzaki, Takeshi Kawauchi   +5 more
doaj   +1 more source