Results 101 to 110 of about 163,366 (294)

Epilepsy‐Associated Variants of a Single SCN1A Codon Exhibit Divergent Functional Properties

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Pathogenic variants in SCN1A, which encodes the voltage‐gated sodium channel NaV1.1, are associated with multiple epilepsy syndromes exhibiting a range of clinical severity. SCN1A variants are reported in different syndromes, including Dravet syndrome, which is associated with loss‐of‐function, whereas neonatal/infantile‐onset ...
Lanie N. Liebovitz, Christopher H. Thompson, Linda C. Laux, Alfred L. George Jr.   +3 more
wiley   +1 more source

RECK in Neural Precursor Cells Plays a Critical Role in Mouse Forebrain Angiogenesis

iScience, 2019
Summary: RECK in neural precursor cells (NPCs) was previously found to support Notch-dependent neurogenesis in mice. On the other hand, recent studies implicate RECK in endothelial cells (ECs) in WNT7-triggered canonical WNT signaling essential for brain
Huiping Li, Takao Miki, Glícia Maria de Almeida, Carina Hanashima, Tomoko Matsuzaki, Calvin J. Kuo, Naoki Watanabe, Makoto Noda   +7 more
doaj   +1 more source

A Systematic Review and Meta‐Analysis of the Recurrence of Autoimmune Encephalitis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Autoimmune encephalitis (AE) is a disease with a potential for recurrence, and patients receive immunotherapy to prevent it. However, there is no consensus on the duration of immunotherapy. This study aimed to determine the recurrence rate and identify the risk factors for AE to provide guidance on the duration of immunotherapy ...
Shangkai Bai, Sen Zhang, Haipei Zhang, Yating Zhang, Junhong Guo, Xiaoyan Yang   +5 more
wiley   +1 more source

Journal of Neuroscience

The nervous system contains complex circuits comprising thousands of cell types and trillions of connections. Here, we discuss how the field of "developmental systems neuroscience" combines the molecular and genetic perspectives of developmental ...
Dooley, James C., van der Heijden, Meike E.   +1 more
core   +1 more source

From early markers to neuro-developmental mechanisms of autism [PDF]

, 2014
A fast growing field, the study of infants at risk because of having an older sibling with autism (i.e. infant sibs) aims to identify the earliest signs of this disorder, which would allow for earlier diagnosis and intervention.
Jones, Emily J.H., Johnson, Mark H., Johnson, M.H., Charman, T., Charman, T.; id_orcid, Johnson, M. H., Jones, E J H, Gliga, Teodora, Johnson, M H, Bedford, R., Jones, E.J.H., Gliga, T., Gliga, T, Charman, T, Bedford, R   +14 more
core   +1 more source

The emergence of the multisensory brain: From the womb to the first steps

iScience
Summary: The becoming of the human being is a multisensory process that starts in the womb. By integrating spontaneous neuronal activity with inputs from the external world, the developing brain learns to make sense of itself through multiple sensory ...
Elena Nava, Michelle Giraud, Nadia Bolognini   +2 more
doaj   +1 more source

Multidimensional Profiling of MRI‐Negative Temporal Lobe Epilepsy Uncovers Distinct Phenotypes

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Although hippocampal sclerosis (TLE‐HS) represents the most frequent cause of temporal lobe epilepsy (TLE), up to 30% of patients show no lesion on visual MRI inspection (TLE‐MRIneg). These cases pose diagnostic and therapeutic challenges and are underrepresented in surgical series.
Alice Ballerini, Alessia Casarini, Niccolò Biagioli, Laura Mirandola, Daniela Ballotta, Paul Summers, Simona Scolastico, Laura Madrassi, Maurilio Genovese, Marcella Malagoli, Gaetano Cantalupo, Giada Giovannini, Matteo Pugnaghi, Niccolò Orlandi, Laura Tassi, Valeria Cuccarini, Domenico Aquino, Elena Tartara, Fulvia Palesi, Giuseppe Didato, Paolo Vitali, the 3TLE Study Group, Roberta Di Giacomo, Fabio Doniselli, Federica Mazzi, Carlo Andrea Galimberti, Claudia A. M. Gandini Wheeler‐Kingshott, Stefano Meletti, Anna Elisabetta Vaudano   +28 more
wiley   +1 more source

Pubertal development of the understanding of social emotions: Implications for education

, 2011
Recent developmental cognitive neuroscience research has supported the notion that puberty and adolescence are periods of profound socio-emotional development.
Blakemore, SJ, Burnett, S., Bird, G, Bird, Geoffrey, Thompson, S., Sarah-Jayne Blakemore, Stephanie Thompson, Blakemore, Sarah-Jayne, Stephanie Burnett, Burnett, Stephanie, Geoffrey Bird, Burnett, S, Blakemore, S.J., Thompson, S, Thompson, Stephanie, Bird, Geoffrey; id_orcid   +15 more
core   +1 more source

The Influence of Prior Knowledge on Memory: A Developmental Cognitive Neuroscience Perspective [PDF]

, 2013
Across ontogenetic development, individuals gather manifold experiences during which they detect regularities in their environment and thereby accumulate knowledge.
Garvin eBrod, Yee Lee eShing, Brod, G., Yee Lee Shing, Werkle-Bergner, Markus, Shing, Yee Lee, Markus Werkle-Bergner, Garvin Brod, Markus eWerkle-Bergner, Brod, Garvin, Shing, Y., Werkle-Bergner, M. ; https://orcid.org/   +11 more
core   +1 more source

Innate Immune Reprogramming Mediated by Endogenous Retroelement Dysregulation Drives Multiple Sclerosis Progression

Annals of Clinical and Translational Neurology, EarlyView.
Epigenetic reprogramming in hematopoietic stem and progenitor cells (HSPCs) and downstream myeloid cells, mediated by H3.3 downregulation and endogenous retroelement (ERE) overexpression, contributes to the progression of multiple sclerosis (MS). ABSTRACT Background Skewed myelopoiesis in the bone marrow has been identified as a key driver of multiple ...
Li‐Mei Xiao, Qiu‐Ping Zhao, Run‐Yun Li, Wei Chen, Huan‐Huan Song, Wan‐Jin Chen, Ying Fu   +6 more
wiley   +1 more source