Results 51 to 60 of about 25,080 (259)

Acute exposure of perchlorate on zebrafish larvae: Neurotoxicity during development

Ecotoxicology and Environmental Safety
Objective: This study aimed to assess the acute developmental toxicity of perchlorate exposure and identify its manifestation of neurotoxicity in zebrafish (Danio rerio) model.
Xiaoran Xue, Zaiqiu Zhang, Yang Yang, Lin Hu, Mingyi Zhao, Qingnan He   +5 more
doaj   +1 more source

Multilayer Biobased Poly(ethylene furanoate)/Graphene Oxide Nanofibrous Membranes With Directional Water Transport for Efficient Microplastics Filtration

Advanced Materials Technologies, EarlyView.
A self‐assembled multilayer biobased PEF/GO nanofibrous membrane was developed by electrospinning for efficient PLA microplastics (MPs) filtration. The membrane combines superhydrophilicity, directional water transport, mechanical robustness, and a synergistic size‐exclusion interception and electrostatic repulsion MPs separation mechanism, enabling ...
Juraij Kandiyil, Sumayya Ansari, Prasanna Kumar S Mural, Yaser E. Greish, Adnan Younis, Akmal Nazir, Muhammad Z. Iqbal   +6 more
wiley   +1 more source

Review: In vitro Cell Platform for Understanding Developmental Toxicity

Frontiers in Genetics, 2020
Developmental toxicity and its affiliation to long-term health, particularly neurodegenerative disease (ND) has attracted significant attentions in recent years. There is, however, a significant gap in current models to track longitudinal changes arising
Junkai Xie, Kyle Wettschurack, Chongli Yuan, Chongli Yuan   +3 more
doaj   +1 more source

Copper‐Driven Epithelial Barrier Disruption: A Novel Mechanism of COPD Acute Exacerbations Mediated by the TNF‐α/ATP7A Axis

Advanced Science, EarlyView.
This study reveals a copper‐driven mechanism of COPD acute exacerbations mediated by the TNF‐α/ATP7A axis. TNF‐α suppresses the copper transporter ATP7A via competitive NF‐κB/CREB1/CBP signaling, resulting in intracellular copper accumulation, mitochondrial oxidative stress, and epithelial barrier disruption.
Xinru Xiao, Yongzhe Hao, Ziqi Ding, Zhipeng Wang, Yujia Shi, Yanhua Huang, Chunjian Qi, Qian Zhang   +7 more
wiley   +1 more source

Melatonin protects against fluoride-induced developmental neurotoxicity by alleviating abnormal mitophagy and apoptosis via the PINK1/Parkin pathway

Ecotoxicology and Environmental Safety
Fluoride induces developmental neurotoxicity, although the underlying mechanisms remain unclear. This study aimed to elucidate the roles of mitophagy and apoptosis mediated by the PTEN-induced kinase 1 (PINK1)/E3 ubiquitin-protein ligase Parkin (Parkin ...
Chun Wang, Runjiang Ma, Wenqi Qin, Chulin Yan, Meng Zhang, Yajie Li, Yongkang Liang, Huayong Wu, Jingjing Zhang, Qiang Niu   +9 more
doaj   +1 more source

NeuroSuite for Long‐Term Functional and Structural Studies of Air‐Liquid Interface Cerebral Organoids

Advanced Science, EarlyView.
NeuroSuite provides a modular hardware‐software platform integrating Neuroweb and NeuroMaps to enable long‐term, in situ electrophysiological interrogation of air–liquid interface organoid slices while preserving tissue architecture. Its components can be used together or independently to capture real‐time activity, spatial network dynamics, and ...
Belquis Haider, Sagnik Middya, Daniel J. Lloyd‐Davies‐Sánchez, Nino F. Läubli, Sulay Vora, Jakob Träuble, Rohan N. Krajeski, Yuqing Feng, Daniel Duncko, Josiah S. Riley, Rubén Ruiz‐Mateos Serrano, Ole Paulsen, Madeline A. Lancaster, George G. Malliaras, Gabriele S. Kaminski Schierle   +14 more
wiley   +1 more source

Changes in miRNA Expression Profiling during Neuronal Differentiation and Methyl Mercury-Induced Toxicity in Human in Vitro Models

Toxics, 2014
MicroRNAs (miRNAs) are implicated in the epigenetic regulation of several brain developmental processes, such as neurogenesis, neuronal differentiation, neurite outgrowth, and synaptic plasticity. The main aim of this study was to evaluate whether miRNA
Giorgia Pallocca, Marco Fabbri, Silvia Nerini-Molteni, Francesca Pistollato, Dimitra Zagoura, Maria Grazia Sacco, Laura Gribaldo, Susanne Bremer-Hoffmann, Anna Bal-Price   +8 more
doaj   +1 more source

Innate Immunocompetent hiPSC‐Derived Neurospheroids Capture Early CNS Responses to rAAV

Advanced Science, EarlyView.
Knowledge of human CNS immune responses to AAV‐based gene therapies remains limited due to the lack of immune‐competent human models. Here, a hiPSC‐derived 3D neuroimmune platform integrating neurospheroids and microglia is established using stirred‐tank bioreactors.
Catarina M. Gomes, Gabriela Silva, Mafalda Aleixo, Marta Gomes, Daniel Simão, Stephan J. Holtkamp, Diana D. Lobo, Pradeep Harish, Rosalind Jenkins, Lekh N. Dahal, Rui J. Nobre, Luís de Pereira de Almeida, Mark Trautwein, Paula M. Alves, Catarina Brito   +14 more
wiley   +1 more source

Apoptosis as a Mechanism of Developmental Neurotoxicity

, 2018
Apoptosis is a tightly controlled physiological process in which individual cells die without damaging neighboring healthy cells. Apoptosis is crucial for normal neurodevelopment, and altered patterns of apoptotic cell death of neurons and glial cells during development are associated with functional deficits.
Lein, PJ, Supasai, S, Guignet, M
openaire   +3 more sources

Disrupted TFEB/GDNF–cAMP/ATP Coupling Underlies Astrocytic Dysfunction and Depression in LRRK2 G2019S Parkinson's Mice

Advanced Science, EarlyView.
ABSTRACT The LRRK2 G2019S mutation, a Parkinson's disease–linked variant, has been associated with depression‐like phenotypes, but mechanisms remain unclear. We chart age‐dependent behavioral changes and astrocyte reactivity in G2019S mice and define a pathway connecting LRRK2 to TFEB/GDNF signaling, cellular energetics, and inflammation.
Longping Yao, Maryam Hatami, Sumeyye Koc, Qing Jiang, Thomas Skutella, Yuanfeng Zhang   +5 more
wiley   +1 more source