Results 51 to 60 of about 23,637 (256)

Potential developmental neurotoxicity of pesticides used in Europe

Environmental Health, 2008
Pesticides used in agriculture are designed to protect crops against unwanted species, such as weeds, insects, and fungus. Many compounds target the nervous system of insect pests. Because of the similarity in brain biochemistry, such pesticides may also
Grandjean Philippe, Andersen Helle, Bjørling-Poulsen Marina   +2 more
doaj   +1 more source

Review: In vitro Cell Platform for Understanding Developmental Toxicity

Frontiers in Genetics, 2020
Developmental toxicity and its affiliation to long-term health, particularly neurodegenerative disease (ND) has attracted significant attentions in recent years. There is, however, a significant gap in current models to track longitudinal changes arising
Junkai Xie, Kyle Wettschurack, Chongli Yuan, Chongli Yuan   +3 more
doaj   +1 more source

Developmental neurotoxicity testing: A path forward [PDF]

Congenital Anomalies, 2012
AbstractGreat progress has been made over the past 40 years in understanding the hazards of exposure to a small number of developmental neurotoxicants. Lead, polychlorinated biphenyls, and methylmercury are all good examples of science‐based approaches to characterizing the hazard to the developing nervous systems from environmental contaminants ...
Kevin M, Crofton, William R, Mundy, Timothy J, Shafer   +2 more
openaire   +2 more sources

Designing Polymer Nanocomposites for X‐Ray Shielding: Mechanisms, Architectures, and Scalable Processing

Advanced Engineering Materials, EarlyView.
This review highlights advances in lightweight, lead‐free polymer nanocomposites for diagnostic X‐ray shielding. By linking filler chemistry, dispersion, architecture, and photon interaction mechanisms, it establishes structure–performance relationships guiding material design.
Aklilu G. Messele, Hossein Ipakchi, Tizazu H. Mekonnen   +2 more
wiley   +1 more source

Acute exposure of perchlorate on zebrafish larvae: Neurotoxicity during development

Ecotoxicology and Environmental Safety
Objective: This study aimed to assess the acute developmental toxicity of perchlorate exposure and identify its manifestation of neurotoxicity in zebrafish (Danio rerio) model.
Xiaoran Xue, Zaiqiu Zhang, Yang Yang, Lin Hu, Mingyi Zhao, Qingnan He   +5 more
doaj   +1 more source

Detection and Prioritization of Developmentally Neurotoxic and/or Neurotoxic Compounds Using Zebrafish [PDF]

Toxicological Sciences, 2018
The standard methods for toxicity testing using rodent models cannot keep pace with the increasing number of chemicals in our environment due to time and resource limitations. Hence, there is an unmet need for fast, sensitive, and cost-effective alternate models to reliably predict toxicity.
Celia Quevedo, Mamta Behl, Kristen Ryan, Richard S Paules, Aintzane Alday, Arantza Muriana, Ainhoa Alzualde   +6 more
openaire   +2 more sources

Gardiquimod Nanoemulsion Targets Cutaneous Leishmaniasis Lesions Reducing Systemic Toxicity and Parasite Burden

Advanced Healthcare Materials, EarlyView.
Nanoemulsion delivery of a TLR7 agonist enhances safety and promotes colocalization with Leishmania‐infected macrophages in skin lesions, enabling a ∼2‐log reduction in parasite burden. However, tissue‐level constraints and TLR‐driven regulatory feedback generate a mixed immune response that limits complete parasite clearance.
Carmen Palomino‐Cano, M. Carmen Mera‐Delgado, Esther Moreno, Esther Larrea, Lecnia Aguirre, Jonathan Miguel Zanatta, Sónia Barros‐Carvalho, Iola F. Duarte, Ricardo Silvestre, Juan M. Irache, Javier Carrión, Socorro Espuelas   +11 more
wiley   +1 more source

Mesoporous Silica Nanoparticles in Biomedicine: Advances and Prospects

Advanced Materials, EarlyView.
Mesoporous silica nanoparticles offer unique properties like high surface area, tunable pores, and functionalization. They excel in drug delivery, tissue engineering, and stimuli‐responsive therapies, enabling targeted and controlled treatments. With roles in cancer therapy and diagnostics, their clinical translation requires addressing challenges in ...
Miguel Manzano, María Vallet‐Regí
wiley   +1 more source

Melatonin protects against fluoride-induced developmental neurotoxicity by alleviating abnormal mitophagy and apoptosis via the PINK1/Parkin pathway

Ecotoxicology and Environmental Safety
Fluoride induces developmental neurotoxicity, although the underlying mechanisms remain unclear. This study aimed to elucidate the roles of mitophagy and apoptosis mediated by the PTEN-induced kinase 1 (PINK1)/E3 ubiquitin-protein ligase Parkin (Parkin ...
Chun Wang, Runjiang Ma, Wenqi Qin, Chulin Yan, Meng Zhang, Yajie Li, Yongkang Liang, Huayong Wu, Jingjing Zhang, Qiang Niu   +9 more
doaj   +1 more source

Changes in miRNA Expression Profiling during Neuronal Differentiation and Methyl Mercury-Induced Toxicity in Human in Vitro Models

Toxics, 2014
MicroRNAs (miRNAs) are implicated in the epigenetic regulation of several brain developmental processes, such as neurogenesis, neuronal differentiation, neurite outgrowth, and synaptic plasticity. The main aim of this study was to evaluate whether miRNA
Giorgia Pallocca, Marco Fabbri, Silvia Nerini-Molteni, Francesca Pistollato, Dimitra Zagoura, Maria Grazia Sacco, Laura Gribaldo, Susanne Bremer-Hoffmann, Anna Bal-Price   +8 more
doaj   +1 more source