Results 91 to 100 of about 181,058 (246)

Pre-reproductive parental enriching experiences influence progeny’s developmental trajectories [PDF]

, 2018
While the positive effects of environmental enrichment (EE) applied after weaning, in adulthood, during aging, or even in the presence of brain damage have been widely described, the transgenerational effects of pre-reproductive EE have been less ...
Berretta, Erica, Caporali, Paola, Cutuli, Debora, Gelfo, Francesca, Laricchiuta, Daniela, Petrosini, Laura   +5 more
core   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Developmental Plasticity in Child Growth and Maturation

Frontiers in Endocrinology, 2011
The ability of a given genotype to produce different phenotypes in response to different environments is termed "plasticity", and is part of the organism's "adaptability" to environmental cues.
Ze'ev eHochberg
doaj   +1 more source

Synaptic Wnt/GSK3β Signaling Hub in Autism [PDF]

, 2016
Indexación: ScopusHundreds of genes have been associated with autism spectrum disorders (ASDs) and the interaction of weak and de novo variants derive from distinct autistic phenotypes thus making up the "spectrum." The convergence of these variants in ...
Avila, M.E., Caracci, M.O., De Ferrari, G.V.   +2 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

The emerging structure of the Extended Evolutionary Synthesis: where does Evo-Devo fit in? [PDF]

, 2018
The Extended Evolutionary Synthesis (EES) debate is gaining ground in contemporary evolutionary biology. In parallel, a number of philosophical standpoints have emerged in an attempt to clarify what exactly is represented by the EES.
A Fuentes, A Fábregas-Tejeda, A Minelli, A Stoltzfus, A Wagner, A Wilkins, AC Love, AC Love, AC Love, AC Love, Alejandro Fábregas-Tejeda, AP Moczek, B Grant, B Sidlauskas, BH Weber, BK Hall, CH Waddington, D Charlesworth, D Duboule, D Noble, D Noble, DJ Depew, DJ Depew, DJ Futuyma, DJ Futuyma, DJ Nicholson, DR Brooks, E Abouheif, E Danchin, E Jablonka, E Jablonka, E Mayr, E Mayr, E Pennisi, E Pennisi, EH Davidson, EI Svensson, EL Peterson, F Suman, FJ Odling-Smee, Francisco Vergara-Silva, G Caponi, G Dassow von, G Fusco, G Gottlieb, GB Müller, GB Müller, GB Müller, GB Müller, GB Müller, GD Wassermann, GP Wagner, GP Wagner, GP Wagner, GP Wagner, GP Wagner, H Palma, HE Hoekstra, I Brigandt, I Brigandt, I Brigandt, I Hacking, I Lakatos, I Tëmkin, J Jaeger, J Whitfield, JA Endler, James Griesemer, JJ Welch, JL Gaddis, JL Hendrikse, JO Reiss, JR True, JS Wicken, K Laland, K Laland, K Laland, K Raj, KE Willmore, KN Laland, L Craig, L Darden, L Nuño de la Rosa, L Nuño de la Rosa, LI Held, LR Craig, M Casanueva, M Casanueva, M Lynch, M Martínez, M Martínez, M Nei, M Pavličev, M Pavličev, M Pigliucci, M Pigliucci, M Pigliucci, M Pigliucci, M Pigliucci, M Rebeiz, MD Laubichler, MD Laubichler, MD Laubichler, MJ West-Eberhard, MW Kirschner, N Eldredge, N Eldredge, N Irie, N Shubin, P Bateson, P Feyerabend, R Amundson, R Bonduriansky, R Bonduriansky, R Diogo, RA Raff, RG Delisle, RG Delisle, RG Winther, RJ Sommer, RM Burian, S Handschuh, S Oyama, SA Newman, SA Newman, SB Carroll, SB Carroll, SF Gilbert, SH Kellert, SJ Gould, SJ Gould, SM Stanley, T Ingold, T Lewens, T Pievani, T Pievani, T Pievani, T Pradeu, U Dieckmann, U Kutschera, VB Smocovitis, W Arthur, W Arthur, W Arthur, W Callebaut   +144 more
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Differential effects of developmental thermal plasticity across three generations of guppies (Poecilia reticulata): canalization and anticipatory matching

Scientific Reports, 2017
Developmental plasticity can match offspring phenotypes to environmental conditions experienced by parents. Such epigenetic modifications are advantageous when parental conditions anticipate offspring environments.
Amélie Le Roy, Isabella Loughland, Frank Seebacher   +2 more
doaj   +1 more source

Beyond Gazing, Pointing, and Reaching: A Survey of Developmental Robotics [PDF]

, 2003
Developmental robotics is an emerging field located at the intersection of developmental psychology and robotics, that has lately attracted quite some attention.
Lungarella, Max, Metta, Giogio
core   +2 more sources