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Developmental regulation of Suz12 localization
Chromosoma, 2005Chromatin modifications are among the epigenetic alterations essential for genetic reprogramming during development. The Polycomb group (PcG) gene family mediates chromatin modifications that contribute to developmentally regulated transcriptional silencing. Trimethylation of histone H3 on lysine 27, mediated by a PcG protein complex consisting of Eed,
Cecile C, de la Cruz +6 more
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Regulation by proteolysis: Developmental switches
Current Opinion in Microbiology, 1999The energy-dependent proteases originally defined in Escherichia coli have proven to have particularly important roles in bacterial developmental systems, including sporulation in Bacillus subtilis and cell cycle in Caulobacter. Degradation of key regulatory proteins participates, with regulation of synthesis and activity of the regulators, to ensure ...
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Developmental regulation of primitive erythropoiesis
Current Opinion in HematologyPurpose of review In this review, we present an overview of recent studies of primitive erythropoiesis, focusing on advances in deciphering its embryonic origin, defining species-specific differences in its developmental regulation, and better understanding the molecular and metabolic pathways involved in terminal ...
Marlies P, Rossmann, James, Palis
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Developmental regulation of globin gene expression
Journal of Cell Science, 1992ABSTRACT We have used the globin family of genes in chicken to study developmental regulation of gene expression, both at the level of individual interaction of trans-acting factors with local promoters and enhancers, and at the level of chromatin structure.
M, Minie +7 more
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Developmental Regulation of Contractile Protein Genes
Annual Review of Physiology, 1989The developmental regulation of the contractile proteins of the muscle sarco mere is well orchestrated. The proteins appear in concert during differentia tion and accumulate to stoichiometric levels, and their induction can be examined both in vivo and in vitro. These properties make myofibrillogenesis an ideal model for the examination of coordinate
R, Wade, L, Kedes
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Developmental regulation of oligosialylation in zebrafish
Glycoconjugate Journal, 2008Zebrafish appears as a relevant model for the functional study of glycoconjugates along vertebrate's development. Indeed, as a prelude to such studies, we have previously identified a vast array of potentially stage-specific glycoconjugates, which structures are reminiscent of glycosylation pathways common to all vertebrates.
Chang, Lan-Yi +6 more
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Developmental Regulation Through Protein Stability
2002The idea that differential gene expression is critical to the establishment of different cell identities is well-worn into the psyches of all scientists who think about the cellular dynamics of development. Equally commonplace is the idea that temporally and spatially dynamic gene expression is quite often regulated at the level of transcription ...
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Developmentally regulated TCR efficiency
Immunology Today, 2000Mature T cells do not respond to those MHC–peptide complexes that they have been positively selected on as thymocytes, indicating that their activation threshold has been altered. Moreover, effector and memory T cells not only respond faster to antigenic stimulation but also with an increased efficiency, which results in costimulation-independent ...
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Developmental regulation of the cell cycle
Current Opinion in Genetics & Development, 1992The control of metazoan cell proliferation, a problem long the domain of cell culture studies, is now being examined in developing animals. Surprisingly, developmental regulation is mediated at a variety of cell-cycle stages. Highly conserved cell-cycle control mechanisms provide a focus for studying the regulatory processes involved.
R, Saint, P L, Wigley
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Polycystin-2 expression is developmentally regulated
American Journal of Physiology-Renal Physiology, 1999PKD2 encodes a protein of unknown function that is mutated in 15% of autosomal dominant polycystic kidney disease (ADPKD) families. We used polyclonal antisera against PKD2 to examine the pattern of Pkd2 expression in staged mouse embryos. Staining for Pkd2 was documented as early as the 6th embryonic day ( day E6) in the embryonic ectoderm and ...
G S, Markowitz +6 more
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