Results 91 to 100 of about 130,891 (267)

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Characterization of La₂O₃ Nanoparticles and Their Effects on Bacteria, Vero and MG63 Cells, and Zebrafish Development

Bioengineering
This study reports, for the first time, lanthanum oxide (La2O3) nanoparticles (NPs) that simultaneously suppress osteosarcoma MG63 cell proliferation and promote normal Vero cell viability, a dual effect not previously documented for La2O3 or similar ...
Jugal Kishore, Tharaka Srinatha Dunuwilla, Venkatagiri Krishnamoorthy Bupesh Raja, Stanley Abraham Louis, Lokesh Kumar Boopathy, Durai Saravanan, Mzia Zhvania, Manoj Gupta   +7 more
doaj   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Erratum to “Peroxisome Proliferator-Activated Receptors Alpha, Beta, and Gamma mRNA and Protein Expression in Human Fetal Tissues”

PPAR Research, 2010
Barbara D. Abbott, Carmen R. Wood, Andrew M. Watkins, Kaberi P. Das, Christopher S. Lau   +4 more
doaj   +1 more source

Implementing a trilineage differentiation in the ReproTracker assay for improved teratogenicity assessment

Frontiers in Toxicology
IntroductionExposure to teratogenic compounds during pregnancy can lead to significant birth defects. Given the considerable variation in drug responses across species, along with the financial and ethical challenges associated with animal testing, the ...
José M. Horcas-Nieto, Sabine Hartvelt, Luke Flatt, Jing Fang, Esther Lam, Gaonan Zhang, Romy Van Vliet, Marleen Feliksik, Tom Zwetsloot, Connor Philippo, Giel Hendriks, Amer Jamalpoor   +11 more
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Developmental and reproductive toxicity assessment of sporoderm-removed Ganoderma lucidum spores

Frontiers in Cell and Developmental Biology
IntroductionGanoderma lucidum is a fungus used in traditional Chinese medicine with high medicinal value and is also widely used in modern healthcare. Its spores are reported to contain antitumor and anti-inflammatory properties, among other biological ...
Junxiu Liu, Yisheng Song, Yisheng Song, Chuanhuai Chen, Jing Liu, Jing Liu, Siming Zhang, Fang Liu, Fang Liu, Ruiyu Tian, Jinjin Shao, Lili Zhang, Tingli Bian, Ruimin Sun, Li Yu, Shuizhen Pan, Yunxiang Chen, Yaoxian Xuan, Hanbo Wang, Zhenhao Li, Ying Chen, Lijiang Zhang, Lijiang Zhang   +22 more
doaj   +1 more source

Effect of terahertz irradiation on DNA damage repair in living cells

FEBS Open Bio, EarlyView.
We investigated the effect of terahertz (THz) wave irradiation on DNA double‐strand break (DSB) repair in living cells. We found that THz irradiation enhanced DSB repair at specific frequencies, whereas heat treatment inhibited it, indicating that this effect is nonthermal and frequency‐specific.
Yuya Ueno, Shota Yamazaki, Hiromichi Hoshina, Masahiko Harata   +3 more
wiley   +1 more source

Hazards and Health Risks of the Antibacterial Agent Triclosan to Fish: A Review

Journal of Xenobiotics
Triclosan (TCS) is a widely used antimicrobial agent found in personal care products and household cleaners. While valued since the 1960s for its ability to inhibit bacterial fatty acid synthesis, its environmental persistence, ecotoxicity, and ...
Jiangang Wang, Nannan Ma, Gancong Mo, Xian Qin, Jin Zhang, Xiangping Yao, Jiahua Guo, Zewei Sun   +7 more
doaj   +1 more source