Results 111 to 120 of about 2,744,821 (349)

Rethinking developmental toxicity testing: Evolution or revolution?

, 2018
Current developmental toxicity testing adheres largely to protocols suggested in 1966 involving the administration of test compound to pregnant laboratory animals.
dIRAS RA-1, Thompson, Kary E, Foreman, Jennifer, Susan Y. Euling, Prägati S. Coder, Anthony R. Scialli, LaRonda Morford, Julia Hui, Hoberman, Alan M, Aldert H. Piersma, George Daston, Knudsen, Thomas, Susan L. Makris, Makris, Susan L, Kary E. Thompson, Stanislaus, Dinesh, Connie Chen, Piersma, Aldert H, Dinesh Stanislaus, Coder, Prägati S, Hui, Julia, Thomas Knudsen, Chen, Connie, Sub RIVM, Euling, Susan Y, Daston, George, Morford, LaRonda, Scialli, Anthony R, Jennifer Foreman, Alan M. Hoberman   +29 more
core   +1 more source

Ethylene glycol and propylene glycol ethers – Reproductive and developmental toxicity

Medycyna Pracy, 2015
Both ethylene and propylene glycol alkyl ethers (EGAEs and PGAEs, respectively) are widely used, mainly as solvents, in industrial and household products.
Beata Starek-Świechowicz, Andrzej Starek   +1 more
doaj   +1 more source

Coupling Genome-wide Transcriptomics and Developmental Toxicity Profiles in Zebrafish to Characterize Polycyclic Aromatic Hydrocarbon (PAH) Hazard

International Journal of Molecular Sciences, 2019
Polycyclic Aromatic Hydrocarbons (PAHs) are diverse environmental pollutants associated with adverse human health effects. Many studies focus on the carcinogenic effects of a limited number of PAHs and there is an increasing need to understand mechanisms
P. Shankar, Mitra C. Geier, L. Truong, R. Mcclure, Paritosh Pande, K. Waters, Robert L. Tanguay   +6 more
semanticscholar   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Developmental toxicity and alteration of gene expression in zebrafish embryos exposed to PFOS

, 2008
Perfluorooetanesulfonate (PFOS) is a persistent organic pollutant, the potential toxicity of which is causing great concern. In the present study, we employed zebrafish embryos to investigate the developmental toxicity of this compound.
Zhou, Bingsheng, Wu, Rudolf S. S., Shi, Xiongjie, Du, Yongbing, Zhou, BS, Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China, Lam, Paul K. S.   +5 more
core   +1 more source

Gold Nanoparticles Reduce Food Sensation in Caenorhabditis elegans via the Voltage-Gated Channel EGL-19

International Journal of Nanomedicine, 2023
Meimei Wang,1,* Zhenzhen Zhang,2,* Ning Sun,3 Baolin Yang,4 Jihao Mo,5 Daping Wang,2 Mingqin Su,1 Jian Hu,1 Miaomiao Wang,6 Lei Wang7,8 1Department of Pathophysiology, School of Basic Medical Science, Anhui Medical University, Hefei, Anhui ...
Wang M, Zhang Z, Sun N, Yang B, Mo J, Wang D, Su M, Hu J, Wang M, Wang L   +9 more
doaj  

Refined reference doses and new procedures for phthalate mixture risk assessment focused on male developmental toxicity.

International Journal of Hygiene and Environmental Health, 2019
New procedures for phthalate mixture risk assessments (MRAs) focused on male developmental toxicity (anti-androgenicity) are overdue. Previous efforts suffer from several shortcomings: There is a lack of consistency in terms of the phthalates entered ...
A. Kortenkamp, H. Koch
semanticscholar   +1 more source

Transcriptomics in developmental toxicity testing

EXCLI journal, 2013
EXCLI Journal ; Vol.
openaire   +3 more sources

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source